Update on cardio-oncology: Novel cancer therapeutics and associated cardiotoxicities.

Trends Cardiovasc Med

Cardio-Oncology Program, Division of Cardiovascular Medicine, University of South Florida, 2 Tampa General Circle, Tampa, FL, 33606, USA; Cardio-Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 USF Magnolia Drive, Tampa, FL, 33612, USA. Electronic address:

Published: January 2019

There have been significant advances in the field of oncology leading to improved survival as a result of novel targeted and immunotherapies. Despite these improved outcomes, there is increased recognition of cardiotoxicities associated with these therapies that can lead to significant morbidity and mortality. As such, the field of cardio-oncology has seen significant growth over the last several years. In this review, we discuss recent advances in the field of cardio-oncology and provide a detailed discussion of the cardiovascular complications associated with novel cancer therapeutics including tyrosine kinase inhibitors, proteasome inhibitors, histone deacetylase inhibitors, CDK4/6 inhibitors and immunotherapies.

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http://dx.doi.org/10.1016/j.tcm.2018.06.001DOI Listing

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