AI Article Synopsis
- Strains of E. coli that produce colibactin may contribute to colorectal cancer (CRC), highlighting the complex relationship between this usually harmless bacteria and cancer development.
- Evidence is presented supporting both the harmful implications of colibactin and alternative observations that challenge the idea that these E. coli strains directly cause CRC.
- An alternative hypothesis suggests that E. coli may preferentially colonize cancerous tissues rather than causing cancer, with colibactin helping these bacteria gain a competitive edge against others in the environment.
Article Abstract
To the multiple factors that may eventually result in colorectal cancer (CRC), strains of E. coli have now been added, in particular strains producing colibactin from their polyketide synthesis (pks) locus. The evidence and mechanistic explanations for this unfortunate effect of what is in most cases a harmless commensal are discussed in the first part of this review. In the second part, observations are presented and discussed that do not fit with the hypothesis that colibactin-producing E. coli produce CRC. The last part of this review is reserved for an alternative explanation of the function of this enigmatic colibactin, a toxin that has not yet been isolated. It is hypothesized that E. coli preferentially colonizes cancerous lesions as an effect rather than a cause and that colibactin production provides a selective advantage to compete with other bacteria.
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| http://dx.doi.org/10.1080/1040841X.2018.1481013 | DOI Listing |
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