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Albendazole-ivermectin co-formulation for the treatment of Trichuris trichiura and other soil-transmitted helminths: a randomised phase 2/3 trial.
Lancet Infect Dis
January 2025
Barcelona Institute for Global Health, Barcelona, Spain; International Health Department, Hospital Clinic de Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain. Electronic address:
Background: Treatments for soil-transmitted helminthiases face challenges, especially in addressing Trichuris trichiura. Combination regimens, particularly of ivermectin and albendazole, are promising. We aimed to assess the safety, efficacy, and palatability of a combination tablet for the treatment of T trichiura, hookworm, and Strongyloides stercoralis infections among school-aged children in Ethiopia, Kenya, and Mozambique.
View Article and Find Full Text PDFThe first case of alveolar echinococcosis from southern Croatia: progressive course of the disease in an immunocompromised patient.
Germs
September 2024
MD, PhD, Infectious Diseases Department, University Hospital of Split, HR-21000 Split, Croatia, and University of Split School of Medicine, HR-21000 Split, Croatia, and University Department of Health Studies of the University of Split, HR-21000 Split, Croatia.
Introduction: Alveolar echinococcosis is one of the most pathogenic zoonoses caused by the larval forms of . It is endemic in central Europe, but from 2001 to 2018, eight European countries reported their first cases of alveolar echinococcosis. These numbers testify to unprecedented spread of the infection.
View Article and Find Full Text PDFCombining solubilization and controlled release strategies to prepare pH-sensitive solid dispersion loaded with albendazole: and studies.
Front Vet Sci
December 2024
Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University (SCAU), Guangzhou, China.
Albendazole (ABZ), classified as a class II basic drug under the Biopharmaceutics Classification System (BCS), is widely recognized for its therapeutic efficacy in treating and preventing trichuriasis. However, despite its clinical relevance, ABZ's oral administration presents challenges due to its poor solubility and pH sensitivity, which diminish its therapeutic effectiveness. Additionally, high dosing regimens of ABZ pose risks of developmental toxicity in animal models.
View Article and Find Full Text PDFAnthelmintic Potential of Discarded Seeds: a sustainable approach to agricultural by-product utilization.
J Pharmacopuncture
December 2024
Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
Objectives: (Sonn.), belonging to the Sapindaceae family, has historically been used for the treatment of gastrointestinal ailments, including ulcers, gastritis, diarrhea, and infections Plants in the Sapindaceae family have demonstrated potential anthelmintic effects, while the efficacy of remains barely investigated. seeds are often discarded as waste; however, utilizing these seeds promotes sustainable practices and may provide a natural alternative to conventional anthelmintics.
View Article and Find Full Text PDFCationized albumin conjugated solid lipid nanoparticles as vectors for delivery of albendazole against cystic echinococcosis.
Parasit Vectors
December 2024
Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Background: Cystic echinococcosis (CE) is a common neglected parasitic disease. Nanoparticles containing drugs have been widely utilized in various formulations for several purposes, including improving the bioavailability of drugs by increasing the solubility and dissolution rate of the nanoparticles. The purpose of this study was to evaluate the effects of solid lipid nanoparticles containing albendazole and conjugated to albumin (B-SLN + ABZ) as a novel treatment approach for hydatid cysts in vivo.
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