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Development of cefepime-induced encephalopathy in a patient with depression and rectal cancer: A case report.
Neuropsychopharmacol Rep
March 2025
National Cancer Center Hospital, Tokyo, Japan.
Article Synopsis
- Cefepime, a fourth-generation antibiotic, can cause neurotoxic side effects like encephalopathy, particularly in patients with compromised blood-brain barriers (BBB) and renal issues.
- A case study of a 79-year-old woman with depression and cancer demonstrated that after receiving cefepime, she developed confusion and other neurological symptoms without apparent brain damage or kidney dysfunction.
- The case suggests that depression and cancer may increase the risk of cefepime-induced encephalopathy, highlighting the need for doctors to monitor such patients closely to avoid misdiagnosis and ensure proper treatment.
Cefepime is a fourth-generation cephalosporin antibiotic administered intravenously used to treat various bacterial infections, including urinary tract infections. Administering cefepime to patients should be done with caution, understanding both potential risks and side effects. A 74-year-old female presented to the family medicine clinic with abdominal pain and a history of urinary tract infections.
View Article and Find Full Text PDFCefepime Induced Neurotoxicity in Patients With or Without a History of Seizures: A Retrospective Matched Cohort Study.
J Pharm Pract
February 2025
Department of Medicine, Division of Infectious Disease, Rutgers New Jersey Medical School, Newark, NJ, USA.
Cefepime is used for the treatment of nosocomial infections and serves as a carbapenem-sparing agent for treating AmpC inducible bacteria. Cefepime induced neurotoxicity (CIN) is a well-documented adverse effect, although data describing the risk of CIN in patients with a history of seizures (HOS) remains limited. The primary and secondary objectives were to compare the rates of CIN in patients with and without HOS and identify risk factors associated with CIN, respectively.
View Article and Find Full Text PDFCefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit.
J Investig Med High Impact Case Rep
July 2024
Joan Edwards School of Medicine, Huntington, WV, USA.
Article Synopsis
- - Cefepime, a fourth-generation antibiotic, has extended antimicrobial capabilities but can cause serious side effects like myoclonus and seizures, particularly in patients with kidney issues.
- - A 69-year-old patient treated with cefepime for pneumonia experienced mental status changes that led to the diagnosis of encephalopathy, even with normal kidney function.
- - The patient's symptoms completely resolved after stopping cefepime, and the report includes similar cases found in medical literature up to now.
Case Report: Cefepime Induced Neurotoxicity Following a Change in Infusion Time.
Hosp Pharm
August 2024
Lexington VA Health Care System, Lexington, KY, USA.
Cefepime is an antibiotic associated with cefepime induced neurotoxicity (CIN), particularly in those with reduced renal function, or in cases of inappropriate medication dosing. This report describes a case of CIN associated with a change in infusion duration from 180 to30 minutes, which to the best of our knowledge has not been previously reported in the literature. A 73-year old male was treated with extended infusion cefepime over 180 minutes while hospitalized with recurrent pneumonia.
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