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Filename: controllers/Detail.php
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Objective: This study aimed to investigate whether endometrial tissues and endometrial epithelial cells were capable of secreting beta-defensin (BD)-1 and -2, and soy isoflavones genistein or daidzein could promote these BD secretions. The effect of genistein on Cl- secretion in correlation with the BD secretion was also examined.
Material And Method: Endometrial tissues or glandular epithelial cell monolayer were mounted in Ussing chamber for measurement of electrical parameters. The sample solutions from apical and basolateral compartments were collected before and after genistein or daidzein addition for the measurement of BD-1 and-2 levels by using ELISA technique.
Results: Endometrial tissues and epithelial cells constitutively secreted both BD-1 and -2 mostly at the apical compartment. Both genistein and daidzein induced BDs secretion which reached a peak at 5-15 min. The apical secretion of BDs was coincidence with increased Cl- secretion induced by genistein.
Conclusion: Endometrial tissues and epithelial cells contributes to basal host defense against infection by secretion of BD-1 and -2, which could be enhanced by genistein or daidzein. This finding implies that these potent constituents of soy isoflavones may be useful to promote the innate immune function of human endometrium.
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Decidualization of endometrial stromal cells is a prerequisite for successful embryo implantation and early pregnancy. Decidualization dysregulation results in implantation failure. In our previous study, we reported that PAI-1 is abnormally downregulated in the endometrial tissue samples of patients with recurrent implantation failure.
View Article and Find Full Text PDFMol Med Rep
March 2025
Key Laboratory for Experimental Teratology of Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P.R. China.
Endometriosis (EM) is a chronic inflammatory disease that is one of the most common causes of gynecological systemic lesions in women before menopause. The most representative histological feature of EM is that the endometrium appears outside of the uterine cavity, often in the ovary. Although it is generally accepted that the epithelial and stromal cells of the ectopic endometrium are not malignant, they still have numerous similarities to malignant tumors, including considerable changes to the immune microenvironment (immune monitoring disorder), the creation of a specific hormone environment, high levels of oxidative stress, chronic inflammation and abnormal immune cell regulation.
View Article and Find Full Text PDFData Brief
December 2024
GenPhySE, Université de Toulouse, INRAE, INPT, ENVT, F31326 Castanet Tolosan, France.
Limiting the level of piglet losses before weaning is a growing demand from producers and society to improve the welfare and health of sows and piglets. In particular, perinatal mortality, which can be defined as the complete development allowing survival at birth, is mostly due to reduced piglet maturity that occurs at the end of gestation. Fetal growth and maturation depend on a fine balance between the nutrient requirements for optimal fetal growth and the maternal nutrient requirements.
View Article and Find Full Text PDFStem Cell Res Ther
December 2024
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Background: Intrauterine adhesion (IUA), resulting from uterine trauma, is one of the major causes of female infertility. Previous studies have demonstrated that endometrial mesenchymal stem cells (eMSC) have therapeutic effects on IUA through cellular secretions. It is particularly true for most of the pre-clinical experiments performed on multiple animal models, as human-derived eMSC cannot maintain long-term engraftment in animals.
View Article and Find Full Text PDFVet Res Commun
December 2024
Facultad de Ciencias Veterinarias (FCV), Universidad Nacional del Litoral (UNL), Esperanza, Santa Fe, Argentina.
In dairy herds, it is expected that cows will be cycling and the uterus will be ready for a new conception before the fourth week postpartum. However, an alteration in the endometrial remodeling can delay conception, increasing the parturition-to-conception interval, and consequently decreasing the reproductive performance. The endometrial matrix has a relevant participation in the processes of postpartum uterine remodeling.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!