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Ovarian Cancer with TTF-1-positive Giant Pleural Dissemination.
Intern Med
October 2024
Department of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Thyroid transcription factor 1 (TTF-1) is primarily expressed in lung and thyroid cancers, but it has also been observed in other cancers. A 60-year-old woman presented with worsening dyspnea, pleural effusion, lung metastases, a right ovarian tumor, and para-aortic intra-abdominal lymph node metastasis. Biopsies from the pleural dissemination revealed TTF-1-positive adenocarcinomas.
View Article and Find Full Text PDFGiant cell carcinoma of the urinary bladder : Clinicopathologic analysis and oncological outcomes.
Virchows Arch
September 2024
Department of Pathology and Laboratory Medicine, Department of Surgery/Urology, Warren Alpert Medical School of Brown University, Lifespan Health, and The Legorreta Cancer Center at Brown University, Providence, RI, USA.
Article Synopsis
- The study analyzes 23 cases of giant cell urothelial carcinoma, a rare type of bladder cancer noted for its distinctive features classified by the World Health Organization.
- Histologically, the tumors displayed a range of structures, often containing a significant giant cell component, alongside other types of differentiated cancers.
- Patients diagnosed with this subtype had a higher incidence of advanced disease and showed differing survival rates compared to conventional urothelial carcinoma, suggesting a poorer prognosis overall.
Inflammatory Giant Cell Carcinoma of the Lung: Clinicopathologic, Immunohistochemical, and Next-generation Sequencing Study of 14 Cases.
Am J Surg Pathol
October 2024
Department of Pathology, Rutgers University, New Jersey Medical School, Newark, NJ.
A distinctive histological variant of poorly differentiated, sarcomatoid, non-small cell lung carcinoma characterized by a discohesive population of giant tumor cells associated with prominent interstitial inflammatory cell infiltrates is described. The tumors occurred in 7 women and 7 men, 42 to 72 years of age (mean: 56 y). They predominantly affected the upper lobes and measured 1.
View Article and Find Full Text PDFCarcinogenic effect of human tumor-derived cell-free filtrates in nude mice.
Front Mol Biosci
April 2024
Center for Genetic Engineering and Biotechnology, Biomedical Research Direction, Havana, Cuba.
Cancer remains a worldwide cause of morbidity and mortality. Investigational research efforts have included the administration of tumor-derived extracts to healthy animals. Having previously demonstrated that the administration of non-transmissible, human cancer-derived homogenates induced malignant tumors in mice, here, we examined the consequences of administering 50 or 100 µg of protein of crude homogenates from mammary carcinoma, pancreatic adenocarcinoma, and melanoma samples in 6 inoculations per week during 2 months.
View Article and Find Full Text PDFPathological response and tumor stroma immunogenic features predict long-term survival in non-small cell lung cancer after neoadjuvant chemotherapy.
Cell Oncol (Dordr)
June 2024
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Purpose: Major pathological response (MPR) has become a surrogate endpoint for overall survival (OS) in non-small cell lung cancer (NSCLC) after neoadjuvant therapy, however, the prognostic histologic features and optimal N descriptor after neoadjuvant therapy are poorly defined.
Methods: We retrospectively analyzed data from 368 NSCLC patients who underwent surgery after neoadjuvant chemotherapy (NAC) from January 2010 to December 2020. The percentage of residual viable tumors in the primary tumor, lymph nodes (LN), and inflammation components within the tumor stroma were comprehensively reviewed.
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