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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990667 | PMC |
| http://dx.doi.org/10.1016/j.vgie.2017.01.008 | DOI Listing |
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Intestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration.
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Department of Neurology, Division of Infectious Diseases, Washington University School of Medicine, St. Louis MO 63110 USA.
Background: The intestinal microbiota regulates normal brain physiology and the pathogenesis of several neurological disorders. While prior studies suggested that this regulation operates through immune cells, the underlying mechanisms remain unclear. Leveraging two well characterized murine models of low-grade glioma (LGG) occurring in the setting of the neurofibromatosis type 1 (NF1) cancer predisposition syndrome, we sought to determine the impact of the gut microbiome on optic glioma progression.
View Article and Find Full Text PDFMouse models are vital tools for discerning the relative contributions of host and microbial genetics to disease, often requiring the transplantation of microbiota between different mouse strains. Transfer methods include antibiotic treatment of recipients and colonization using either co-housing with donors or the transplantation of fecal or cecal donor material. However, the efficiency and dynamics of these methods in reconstituting recipients with donor microbes is not well understood.
View Article and Find Full Text PDFBackground: Neonatal mice are frequently used to model diseases that affect human infants. Microbial community composition has been shown to impact disease progression in these models. Despite this, the maturation of the early-life murine microbiome has not been well-characterized.
View Article and Find Full Text PDFCoconut ( L.) and Carob ( L.) Flours Dietary Fibers Differentially Impact Fecal Microbiota Composition and Metabolic Outputs In Vitro.
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Food Engineering Department, Engineering Faculty Necmettin Erbakan University Konya Türkiye.
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View Article and Find Full Text PDFThe bacterial composition signatures of perianal abscess and origin of infecting microbes.
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Department of Anorectal Surgery, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Qingdao, China.
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