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| http://dx.doi.org/10.1016/j.vgie.2016.07.011 | DOI Listing |
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Recellularization via electroporation therapy of the duodenum combined with glucagon-like peptide-1 receptor agonist to replace insulin therapy in patients with type 2 diabetes: 12-month results of a first-in-human study.
Gastrointest Endosc
November 2024
Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- * The study included 14 patients on insulin, where ReCET was performed with optimized electroporation doses, and patients were switched to a glucagon-like peptide 1 receptor agonist afterwards.
- * Results indicated that ReCET was safe and effective, with 86% of patients remaining off insulin after 12 months and showing significant improvements in their blood sugar levels.
Endoscopic duodenal mucosa ablation techniques for diabetes and nonalcoholic fatty liver disease: A systematic review.
Med
July 2024
Department of Medical Sciences, Città della Salute e della Scienza, University of Turin, Turin, Italy.
Background: Type 2 diabetes mellitus (T2DM) is increasing at an alarming rate, and only 50% of patients with T2DM achieve or maintain adequate glycemic control with pharmacological therapies. Metabolic surgery demonstrated superior efficacy compared to medical therapy but is unfeasible for most patients with T2DM. Duodenal mucosal resurfacing (DMR) by hydrothermal mucosal ablation, recellularization via electroporation therapy (ReCET), and photodynamic therapy are novel endoscopic procedures that use thermal, electrical, and photochemical energy, respectively, to ablate and reset dysfunctional duodenal mucosa.
View Article and Find Full Text PDFInsulin sensitivity and beta cell function after duodenal mucosal resurfacing: an open-label, mechanistic, pilot study.
Gastrointest Endosc
September 2024
Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands.
Background And Aims: The duodenum has been shown to play a key role in glucose homeostasis. Duodenal mucosal resurfacing (DMR) is an endoscopic procedure for patients with type 2 diabetes (T2D) in which the duodenal mucosa is hydrothermally ablated. DMR improves glycemic control, but the underlying mechanisms remain unclear.
View Article and Find Full Text PDFSurfactant-like photosensitizer for endoscopic duodenal ablation: Modulating meal-stimulated incretin hormones in obese and type 2 diabetes.
Biomaterials
November 2023
Department of Biotechnology, Department of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea. Electronic address:
Duodenal ablation improves glycaemic control and weight loss, so it has been applied using hydrothermal catheters in obese and type 2 diabetes patients, indicating similar mechanisms and therapeutic effects as bariatric surgeries. Endoscopic photodynamic therapy is an innovative procedure that easily accessible to endocrine or gastrointestinal organs, so it is critical for the sprayed photosensitizer (PS) to long-term interact with target tissues for enhancing its effects. Surfactant-like PS was more stable in a wide range of pH and 2.
View Article and Find Full Text PDFA Changed Gut Microbiota Diversity Is Associated With Metabolic Improvements After Duodenal Mucosal Resurfacing With Glucagon-Like-Peptide-1 Receptor Agonist in Type 2 Diabetes in a Pilot Study.
Front Clin Diabetes Healthc
July 2022
Gastroenterology and Hepatology, Amsterdam University Medical Centres, Amsterdam, Netherlands.
Article Synopsis
- The gut microbiota plays a crucial role in how our bodies metabolize nutrients and manage digestion, with new procedures like Duodenal Mucosal Resurfacing (DMR) showing promise in improving metabolic health for patients with type 2 diabetes.
- In a study, 69% of insulin-dependent type 2 diabetes patients discontinued insulin treatment after undergoing DMR combined with a glucagon-like peptide-1 receptor agonist, leading to better blood sugar control.
- Analysis of gut microbiota showed correlations between changes in diversity and metabolic health outcomes, but no significant diversity changes were found within three months, indicating that further research is needed to understand these relationships better.
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