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The Lack of Effect of Botulinum Toxin-A on Upper Limb Activity in Chronic Stroke: A Short Report from the InTENSE Trial.
Toxins (Basel)
November 2024
Alfred Health, Melbourne, VIC 3004, Australia.
We examined the effect of botulinum toxin-A on upper limb impairments and activity limitations in chronic stroke. This study is a secondary analysis of control group data from a national, multicenter, Phase III randomized trial with a masked outcome assessment. We studied 71 stroke survivors who received a botulinum toxin-A injection in any muscle(s) that crosses the wrist due to significant spasticity after a stroke greater than 3 months previously.
View Article and Find Full Text PDFPathophysiology and Management of Refractory Trigeminal Neuralgia.
Curr Neurol Neurosci Rep
December 2024
Department of Neurology, Headache Division, Mayo Clinic, Rochester, MN, USA.
Purpose Of Review: Discuss the current understanding of the pathophysiology and management of refractory trigeminal neuralgia (TN). This includes a discussion on why TN can recur after microvascular decompression and a discussion on "outside of the box" options when both first- and second-line management strategies have been exhausted.
Recent Findings: This review discusses second- and third-line oral medication options, botulinum toxin A, repeat microvascular decompression, repeat ablative procedures, internal neurolysis, trigeminal branch blockade, and neuromodulation using TMS or peripheral stimulation.
Botulinum toxin injection versus lateral internal sphincterotomy for chronic anal fissure: a meta-analysis of randomized control trials.
Langenbecks Arch Surg
November 2024
Jiroft University of Medical Sciences, Jiroft, Iran.
Background: Anal fissures, tears in the epithelium of the anal canal that cause pain and bleeding, have a lifetime prevalence of 11%. While surgical treatments, such as lateral internal sphincterotomy are traditional, they pose postoperative complications. Recent studies investigated less invasive options involving botulinum toxin injection, showing promise with fewer adverse effects.
View Article and Find Full Text PDFTrends in Overactive Bladder Therapy: Associations Between Clinical Care Pathways, Practice Guidelines, and Therapy Utilization Patterns.
Neurourol Urodyn
November 2024
Department of Urology, Stanford University, Stanford, California, USA.
Article Synopsis
- Overactive bladder (OAB) is a long-term condition affecting health and finances, and guidelines were created to improve its management, but the effectiveness of these guidelines remains unclear.
- A study analyzed data from a national health claims database (Optum) between 2013 and 2018 to evaluate trends in OAB treatment, focusing on medication and minimally invasive therapies post-2014 guideline updates.
- The research included over 1.8 million patients, revealing a significant increase in new OAB diagnoses (369%) and providing insights into therapy utilization patterns based on various demographic factors.
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