AI Article Synopsis
- The study investigates how mesenchymal stem cell transplantation (MSCT) works differently for patients with rheumatoid arthritis (RA) and seeks a serum biomarker to predict its effectiveness.
- Analyzed 105 RA patients poorly responding to traditional treatments, dividing them into MSCT and control groups, measuring outcomes such as disease activity scores and cytokine levels over 12 weeks.
- Results showed no significant adverse effects from MSCT, with effective treatment lasting 48 weeks, and a notable increase in serum IFN-γ levels in patients who responded well, suggesting it could serve as a key biomarker for predicting MSCT success.
Article Abstract
Background: To explore the mechanism of the different clinical efficacies of mesenchymal stem cell transplantation (MSCT) and identify a possible serum biomarker for predicting the therapeutic effect of MSCT in rheumatoid arthritis (RA) patients.
Methods: A total of 105 patients with persistently active RA and poor responses to traditional medication were randomly divided into MSCT and control groups. Outcomes were evaluated according to the 28-joint Disease Activity Score and Health Assessment Questionnaire, serological indicators, regulatory T cell (Treg) to T helper 17 (Th17) cell ratio, and inflammatory cytokine levels. Twelve weeks after MSCT, the outcomes of the MSCT group were evaluated according to the European League against Rheumatism response criteria. Patients with a good or moderate response were added to the response group, and those with no response were added to the no-response group.
Results: No serious adverse events were reported for either MSCT subgroup (28 in the response group and 24 in the no-response group). The therapeutic effects lasted for 48 weeks without continuous administration. Notably, a transient increase in serum IFN-γ (>2 pg/ml) levels was observed in the response group, but not in the no-response group. Furthermore, an increase in IL-10 levels and the Treg/Th17 ratio and a reduction in IL-6 levels appeared 2-3 weeks after the transient IFN-γ increase.
Conclusions: Allogeneic MSCT is safe and feasible, and we propose high serum IFN-γ levels as a potent biomarker for predicting MSCT response. Trial registration chictr.org, ChiCTR-ONC-16008770. Registered 3 July 2016, http://www.chictr.org.cn/showproj.aspx?proj=14820.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003078 | PMC |
| http://dx.doi.org/10.1186/s12967-018-1541-4 | DOI Listing |
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