Purpose Of Review: The incidence of pediatric nephrolithiasis is on the rise, with a significant related morbidity and a concomitant relevant increase in healthcare costs. The purpose of this review is to portray the current epidemiology and cause of renal stones in children, to provide a framework for appropriate clinical evaluation on an individual basis, and a guidance regarding treatment and prevention for the significant risk of lifelong recurrence and deriving complications.
Recent Findings: The early identification of modifiable risk factors and other abnormalities is essential, to prevent related morbidity, the onset of chronic kidney disease, and the associated increased risk of developing other diseases. The implementation of risk reduction strategies, including dietary modifications and targeted pharmacological therapies, will significantly influence stone recurrences and preserve renal function.
Summary: Future research is desirable, with the aim to strengthen personalized conservative management of pediatric nephrolithiasis as first-line treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MOU.0000000000000520 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human liver cell-based assays for the prediction of hepatic bile acid efflux transporter inhibition by drugs.
Expert Opin Drug Metab Toxicol
January 2025
Institut de R&D Servier, Paris-Saclay, F-91190 Gif-sur-Yvette, France.
Introduction: Drug-mediated inhibition of bile salt efflux transporters may cause liver injury. In vitro prediction of drug effects toward canalicular and/or sinusoidal efflux of bile salts from human hepatocytes is therefore a major issue, which can be addressed using liver cell-based assays.
Area Covered: This review, based on a thorough literature search in the scientific databases PubMed and Web of Science, provides key information about hepatic transporters implicated in bile salt efflux, the human liver cell models available for investigating functional inhibition of bile salt efflux, the different methodologies used for this purpose, and the modes of expression of the results.
The prognostic value of changes in Ki67 following neoadjuvant chemotherapy in residual triple-negative breast cancer: a Swedish nationwide registry-based study.
Breast Cancer Res Treat
January 2025
Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Article Synopsis
- The study investigates how changes in the Ki67 biomarker before and after neoadjuvant chemotherapy (NACT) affect survival in patients with triple-negative breast cancer (TNBC).
- Among 1,777 TNBC patients analyzed, most showed a decrease in tumor size and Ki67 levels after NACT, though many had no change or experienced treatment discontinuation.
- Patients with unchanged Ki67 had significantly worse overall and disease-specific survival compared to those with decreased Ki67, emphasizing the need for personalized treatment strategies based on ongoing monitoring of this biomarker.
Combining an Anterolateral Complex Procedure With Anterior Cruciate Ligament Reconstruction Reduces Graft Reinjury Without Increasing the Rate of Complications: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Am J Sports Med
January 2025
Gelenkpunkt-Sports and Joint Surgery FIFA Medical Centre of Excellence, Innsbruck, Austria.
Background: Anterolateral ligament reconstruction (ALLR) or lateral extra-articular tenodesis (LET) has been used more frequently in conjunction with anterior cruciate ligament reconstruction (ACLR) in recent years. However, there are still concerns that these procedures may lead to complications such as overconstraint of the lateral compartment, stiffness, infections, tunnel convergence, and other intra- and postoperative complications because of increased surgical time and the need for additional procedures.
Hypothesis/purpose: The lateral extra-articular procedure will reduce the failure rate of reconstructed ACLs without increasing the number of complications.
Biomechanical Properties of Meniscal Repair Versus Meniscectomy for Horizontal Meniscal Tears: A Systematic Review.
Am J Sports Med
January 2025
Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Article Synopsis
- Limited biomechanical research explores how horizontal meniscus tears (HMTs), meniscal repair (MR), and meniscectomy affect knee biomechanics, prompting this systematic review to investigate changes in knee contact mechanics following these conditions.
- A total of 6 studies were analyzed, revealing that HMTs increase peak contact pressure (PCP) by 14.2% and decrease contact area (CA) by 7.1%; partial meniscectomies (PM) also raised PCP significantly while reducing CA, and complete meniscectomies (CM) resulted in even higher increases in PCP (54.5%).
- Meniscal repair (MR) showed no significant difference in PCP or CA compared to intact menisci, indicating that it
Chromogenic bacterial staining of teeth: a scoping review.
BMC Oral Health
January 2025
Basic Medical and Dental Sciences Department, College of Dentistry, Ajman University, Ajman, UAE.
Article Synopsis
- This scoping review aims to investigate the causes, clinical traits, and treatment methods for chromogenic staining of teeth, following the PRISMA 2022 guidelines.
- A systematic search across multiple medical databases led to the identification of 989 articles, with 21 ultimately included for analysis, highlighting that chromogenic bacteria can cause staining in 3.1 to 18.5% of cases, primarily resulting in black discoloration.
- The findings indicate a lack of comprehensive literature on this topic, emphasizing the need for further research into effective management strategies for these challenging stains linked to specific oral bacteria.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!