AI Article Synopsis
- Complete stereocontrol was achieved in the hydroboration of allenamides with acetyl groups, producing only the Z-isomer.
- A Pd-catalyzed cross-coupling reaction followed, facilitating the easy creation of trisubstituted enamides.
- This process demonstrated total control over stereoselectivity throughout the reactions.
Article Abstract
Complete stereocontrol on the transition-metal-free hydroboration of the distal double bond of allenamides could be achieved when allenamides contained acetyl substituents, which provided exclusively the Z-isomer. The consecutive Pd-catalyzed cross-coupling reaction allowed the straightforward formation of trisubstituted enamides, with total control of the stereoselectivity.
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| http://dx.doi.org/10.1002/chem.201803004 | DOI Listing |
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