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Captopril has a known hypotensive action derived from the inhibition of the converting enzyme (Kininase II). To investigate whether other mechanism may contribute to vasodilation, Na-K ATPase and Mg ATPase activities on ghost red blood cells membranes were examined in the presence of the drug. The results show a stimulation of Mg ATPase activity and an inhibition of Na-K ATPase activity in a concentration dependent manner. The latter action does not seem to be related to a vasodilator effect.
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| http://dx.doi.org/10.1016/0031-6989(85)90012-8 | DOI Listing |
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