serological assays with improved sensitivity over commercially available assays are needed to evaluate the burden of infection and the effectiveness of prevention efforts. We evaluated the performance of a outer membrane complex protein B (OmcB) enzyme-linked immunosorbent assay (ELISA) in the detection of anti- antibody responses in -infected women. OmcB ELISA was less sensitive than our elementary body (EB) ELISA, but it was highly specific. The magnitude of the antibody response was higher in African-Americans and those with prior infection. Unlike EB ELISA, the IgG1 response to OmcB was short-lived and was not maintained by repeat infection.
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| http://dx.doi.org/10.1128/JCM.00275-18 | DOI Listing |
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