Proteins Potentially Involved in Immune Evasion Strategies in Elucidated by Ultra-High-Resolution Mass Spectrometry.

is the prevalent agent of a large zoonotic outbreak in Brazil. With the involvement of several thousands of cases, this is the largest cohort of human and animal sporotrichosis on record in the world. Infections are characterized by local cutaneous dissemination in humans without underlying disease. has shown a high degree of virulence in a mouse model compared to the remaining species, including the ancestral species, The present paper investigates a genomic and expressed-proteome comparison of to Using bottom-up proteomics, we found 60 proteins exclusively expressed in No significant genomic differences were found among the genes coding for this protein set. A comparison with literature data identified nine proteins that are known to be involved in virulence and immune evasion in other species, several of which had not yet been reported for the species analyzed. Sporotrichosis is an important disease in Brazil that is caused by fungi of the genus and affects cats and humans. Our work investigated the proteins differentially expressed by in order to find out why this species is more virulent and pathogenic than We verified a set of proteins that may be related to immune escape and that can explain the high virulence.