An endophytic fungus from SWUKD3.1610 that produces nigranoic acid and its analogues.

Nat Prod Res

a Key Laboratory of Eco-Environments in Three Gorges Reservoir Region (Ministry of Education), School of Life Science , Southwest University, Chongqing , P.R. China.

Published: July 2019

AI Article Synopsis

  • The study aimed to investigate if endophytic fungi could produce nigranoic acid and its derivatives.
  • Out of 426 fungi tested, SWUKD3.1610 was identified as producing nigranoic acid, confirmed through various chemical analyses.
  • Additionally, the researchers isolated a new compound, 7-schinalactone C, and highlighted the potential of endophytic fungi in enhancing the quality of medicinal plants.

Article Abstract

The objective of this study was to determine whether endophytic fungi, isolated from produce nigranoic acid and its highly oxygenated derivatives. From the 426 endophytic fungi screened, SWUKD3.1610 was detected to have a component with the same TLC value and HPLC retention time as authentic nigranoic acid. This component was further confirmed as nigranoic acid by investigating the chemical composition of the fungal extracts. Besides (), one new triterpenoid, 7- schinalactone C (), and two known minor compounds were isolated and characterized by HRESIMS, 1D and 2D NMR spectroscopic methods. Our study indicates that endophytic fungus may play an important role in increasing the quality of the crude drugs from Chinese medicinal plant . This study is the first to isolate, characterize, and identify schitriterpenes-producing .

Download full-text PDF

Source
http://dx.doi.org/10.1080/14786419.2018.1486311DOI Listing

Publication Analysis

Top Keywords

nigranoic acid
16
endophytic fungus
8
endophytic fungi
8
endophytic
4
fungus swukd31610
4
swukd31610 produces
4
nigranoic
4
produces nigranoic
4
acid
4
acid analogues
4

Similar Publications

[Chemical constituents from roots of Kadsura heteroclita].

Zhongguo Zhong Yao Za Zhi

March 2024

Traditional Chinese Medicine and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.

The dichloromethane fraction of Kadsura heteroclita roots was separated and purified by chromatographic techniques(e.g., silica gel, Sephadex LH-20, ODS, MCI column chromatography) and semi-preparative HPLC.

View Article and Find Full Text PDF

Synthesis of nigranoic acid and manwuweizic acid derivatives as HDAC inhibitors and anti-inflammatory agents.

Bioorg Chem

April 2021

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address:

As a successful anti-tumor drug target, the family of histone deacetylases (HDACs) is also a critical player in immune response, making the research of anti-inflammatory HDAC inhibitors an attractive new focus. In this report, triterpenoids nigranoic acid (NA) and manwuweizic acid (MA) were identified as HDAC inhibitors through docking-based virtual screening and enzymatic activity assay. A series of derivatives of NA and MA were synthesized and assessed for their biological effects.

View Article and Find Full Text PDF

Kadanguslactones A-E, further oxygenated terpenoids from Kadsura angustifolia fermented by a symbiotic endophytic fungus, Penicillium ochrochloron SWUKD4.1850.

Phytochemistry

June 2020

Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation, School of Life Sciences, Southwest University, Chongqing, 400715, People's Republic of China. Electronic address:

The fermentation of Kadsura angustifolia with an endophytic fungus, Penicillium ochrochloron SWUKD4.1850 yielded five additional undescribed oxygenated terpenoids, kadanguslactones A-E, together with ten known compounds. Their structures were established by the extensive 1D, 2D-NMR, HR-ESI-MS, CD and X-ray crystallography data analysis.

View Article and Find Full Text PDF

Effects of an Endophytic Fungus on the Secondary Metabolites of Host-Plant .

Front Microbiol

November 2018

Key Laboratory of Eco-Environments in Three Gorges Reservoir Region (Ministry of Education), School of Life Sciences, Southwest University, Chongqing, China.

Fungal endophytes live widely inside plant tissues and some have been revealed to provide benefits to their host and ecological environment. Considering the fact that endophytes are engaged in remarkably stable long-term interactions with the host for their whole life cycle, it's conceivable that both partners have substantial influence on each other's metabolic processes. Here, we investigated the fermented products of an endophytic fungus SWUKD3.

View Article and Find Full Text PDF

Enhanced production of unusual triterpenoids from Kadsura angustifolia fermented by a symbiont endophytic fungus, Penicillium sp. SWUKD4.1850.

Phytochemistry

February 2019

Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), School of Life Science, Southwest University, Chongqing 400715, China. Electronic address:

Highly oxygenated schitriterpenoids are interesting for study of their structures, bioactivities and synthesis. From Kadsura angustifolia fermented by an associated symbiotic endophytic fungus, Penicillium sp. SWUKD4.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!