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Unlabelled: Transparent and accurate reporting in early phase dose-finding (EPDF) clinical trials is crucial for informing subsequent larger trials. The SPIRIT statement, designed for trial protocol content, does not adequately cover the distinctive features of EPDF trials. Recent findings indicate that the protocol contents in past EPDF trials frequently lacked completeness and clarity.
View Article and Find Full Text PDFDesign and maintenance of medical oxygen concentrators in Sub-Saharan Africa: a systematic review.
BMC Health Serv Res
January 2025
Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome, 00128, Italy.
Background: Oxygen therapy is critical and vital treatment for hypoxemia and respiratory distress, however, access to reliable oxygen systems remains limited in SSA. Despite WHO initiatives that distributed over 30,000 OC oxygen concentrators worldwide, SSA faces significant challenges related to their maintenance and use, due to harsh environmental conditions, technical skill shortages and inadequate infrastructure. This review aims to systematically identify and assess the literature on OC design adaptations, maintenance challenges, and knowledge gaps in SSA, providing actionable recommendations to inform innovative and context-sensitive solutions to improve healthcare delivery in the region.
View Article and Find Full Text PDFReferrals to Peer Support for Families in Pediatric Subspecialty Practices: A Qualitative Study.
Matern Child Health J
January 2025
Lucile Packard Foundation for Children's Health, 400 Hamilton Avenue, Suite 340, Palo Alto, CA, 94301, USA.
Introduction: Referrals to peer support (PS) can help families of children with special health care needs in providing emotional support, reducing feelings of stress and anxiety, and improving the care experience. This study aimed to gain providers' perspectives about PS referrals for families of children with special health care needs, including their perspectives on logistics of, barriers to, and facilitators of making referrals as well as the perceived impacts of PS referrals.
Methods: This study builds on a 2022 survey of California pediatric subspecialists about the value and challenges of PS.
Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulence.
Nat Commun
January 2025
Functional Genomics & Bioinformatics Laboratory, Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea.
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses in the global swine industry due to its high genetic diversity and different virulence levels, which complicate disease management and vaccine development. This study evaluated longitudinal changes in the immune cell composition of bronchoalveolar lavage fluid and the clinical outcomes across PRRSV strains with varying virulence, using techniques including single-cell transcriptomics. In highly virulent infection, faster viral replication results in an earlier peak lung-damage time point, marked by significant interstitial pneumonia, a significant decrease in macrophages, and an influx of lymphocytes.
View Article and Find Full Text PDFOne state's journey with a reflective supervision professional development series: Development, implementation, and adaptation.
Infant Ment Health J
January 2025
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Reflective supervision (RS) has been viewed as best practice and is therefore incorporated-and often mandated-as a key feature of many relationship-based infant and early childhood serving programs. To promote the implementation of high-quality RS for infant and early childhood professionals, it is critical that a focus is placed on how infant and early childhood professionals are trained to build RS capacities. To this end, we describe Rhode Island, United States's journey developing, implementing, and iteratively adapting an RS professional development series.
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