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Lifetime Disability-adjusted Life Year assessment of indolent systemic mastocytosis.
J Allergy Clin Immunol Pract
December 2024
CEREMAST, Dermatology Department, University Hospital, Toulouse, France.
Background: Indolent Systemic Mastocytosis (ISM) is a rare disease associated with numerous and diverse symptoms that significantly impact patients' overall health, psychological, emotional, and professional well-being, ultimately affecting their quality of life.
Objective: We aim to estimate the Disability-adjusted Life Year (DALY) of ISM to assess the burden for patients and society.
Methods: We used prospective and retrospective data on symptoms and quality of life from an ISM population recruited at the French expert center CEREMAST, to estimate Disability Weight allowing DALY calculation.
Single cell transcriptomics reveals dysregulated immnue homeostasis in different stages in HPV-induced cutaneous squamous cell carcinoma.
Exp Dermatol
October 2024
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Article Synopsis
- The study investigates how impaired immune homeostasis affects the development of cutaneous squamous cell carcinoma (cSCC), focusing on a rare, rapidly progressing case of HPV-induced cSCC.* -
- Researchers conducted single-cell RNA sequencing on skin tissues from the patient, revealing specific immune cell changes and interactions that occur during the progression from normal skin to tumor tissue.* -
- This is the first exploration of the correlation between HPV infection and tumor development at various stages, offering insights into the dynamics of immune responses in cSCC.*
Ligusticum chuanxiong Hort.: a review of its phytochemistry, pharmacology, and toxicology.
J Pharm Pharmacol
November 2024
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China.
Background: Conioselinum anthriscoides (H. Boissieu) Pimenov & Kljuykov, also known as Ligusticum chuanxiong Hort. is a perennial Umbelliferae herb, whose dried rhizome commonly called Chuanxiong Rhizoma.
View Article and Find Full Text PDFDistinct adaptive immune receptor feature of adipose-derived mesenchymal stem cells (AD-MSCs) treatment of psoriasis.
Arch Dermatol Res
August 2024
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Clinical College of Guangzhou, University of Chinese Medicine, Guangzhou, 510000, China.
Psoriasis (Ps) is one of the most common chronic inflammatory skin disorders with its pathogenesis correlated with dysregulated innate and adaptive system. Even though biological agents have advanced the treatment of psoriasis, however, there are huge limitations, like high adverse reactions and relapse rate. Therefore, it is of great interest in searching clinical resolutions with better safety and efficacy.
View Article and Find Full Text PDFStructural and functional imaging of psoriasis for severity assessment and quantitative monitoring of treatment response using high-resolution optoacoustic imaging.
Photoacoustics
August 2024
A⁎STAR Skin Research Labs (A⁎SRL), Agency for Science, Technology and Research (A⁎STAR), 31 Biopolis Way, #07-01 Nanos, Singapore 138669, Republic of Singapore.
Article Synopsis
- * A new non-invasive technique called multispectral Raster-Scanning Optoacoustic Mesoscopy (ms-RSOM) is being tested to objectively measure the severity of psoriasis by analyzing skin features, including blood volume and oxygen levels.
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