AI Article Synopsis
- The study introduces the nucleophilic ring opening of donor-acceptor cyclopropanes using cyanate ions, a novel reaction previously unreported.
- Cyclopropanes enhanced with oxindole fragments transform into spiro[pyrrolidone-3,3'-oxindoles], which are biologically significant compounds.
- The reaction is facilitated using potassium cyanate and microwave technology, optimizing the transformation process.
Article Abstract
The nucleophilic ring opening of donor-acceptor cyclopropanes with the cyanate ion is reported for the first time. Cyclopropanes, spiro-activated with oxindole fragments as acceptors, are shown to undergo transformations into biologically relevant spiro[pyrrolidone-3,3'-oxindoles] while being treated with potassium cyanate under microwave assistance.
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| http://dx.doi.org/10.1021/acs.joc.8b00922 | DOI Listing |
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