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Disseminated protothecosis in a dog coinfected with Hepatozoon canis and Ehrlichia canis.
Vet Res Commun
January 2025
Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
Protothecosis is a severe, emerging opportunistic infection caused by the saprophytic, achlorophyllous microalgae of the genus Prototheca. Though uncommon, human and animal cases are increasing worldwide, making awareness of this fungal-like pathogen important in both human and veterinary medicine. We report a fatal case of disseminated protothecosis caused by P.
View Article and Find Full Text PDFThe emerging role of photodynamic therapy in the treatment of cutaneous infections.
Ital J Dermatol Venerol
February 2025
Department of Dermatology, University of California, Irvine, CA, USA -
Introduction: Cutaneous infections pose ongoing challenges to standard treatments due to resistance and limited efficacy. Photodynamic therapy (PDT) emerges as a promising supplement or an alternative to address complicated cases. In this review, we comprehensively review PDT's safety and efficacy in treating cutaneous infections.
View Article and Find Full Text PDFSafety and effectiveness of guselkumab in Japanese patients with psoriasis: 20-week interim analysis of a postmarketing surveillance study.
J Dermatol
June 2024
Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.
Article Synopsis
- A 52-week study assessed the safety and effectiveness of guselkumab, a monoclonal antibody used to treat various forms of psoriasis in Japanese patients, with reported results from a 20-week interim analysis.
- Out of 411 patients analyzed for safety, 6.6% experienced adverse drug reactions (ADRs), with the most common being infections, while 2.2% had serious ADRs.
- Improvements in psoriasis severity were significant, with scores dropping from 11.6 at baseline to 2.2 by week 20, highlighting guselkumab's tolerability and effectiveness in real-world settings.
How effective is topical miconazole or amorolfine for mild to moderately severe onychomycosis in primary care: the Onycho Trial - a randomised double-blind placebo-controlled trial.
BMJ Open
May 2024
Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Objectives: To evaluate the efficacy of topical miconazole or amorolfine compared to placebo for mild to moderately severe onychomycosis.
Design: Randomised, double-blind, placebo-controlled trial, with computer-generated treatment allocation at a 1:1:1 ratio.
Setting: Primary care, recruitment from February 2020 to August 2022.
Ungual Scabies: A Case Report and Review of Literature.
Skin Appendage Disord
February 2024
Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
Introduction: Nail unit infestation by scabies mites (ungual scabies) is uncommon. It usually presents with distal subungual lesions, leading to recurrent and persistent disease by acting as a reservoir of infection. Periungual involvement in scabies with nail loss is rare and may lead to severe nail damage.
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