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Acetylcholinesterase and Aβ Aggregation Inhibition by Heterometallic Ruthenium(II)-Platinum(II) Polypyridyl Complexes. | LitMetric
Two heteronuclear ruthenium(II)-platinum(II) complexes [Ru(bpy)(BPIMBp)PtCl] (3) and [Ru(phen)(BPIMBp)PtCl] (4), where bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, and BPIMBp = 1,4'-bis[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1'-biphenyl, have been designed and synthesized from their mononuclear precursors [Ru(bpy)(BPIMBp)] (1) and [Ru(phen)(BPIMBp)] (2) as multitarget molecules for Alzheimer's disease (AD). The inclusion of the cis-PtCl moiety facilitates the covalent interaction of Ru(II) polypyridyl complexes with amyloid β (Aβ) peptide. These multifunctional complexes act as inhibitors of acetylcholinesterase (AChE), Aβ aggregation, and Cu-induced oxidative stress and protect neuronal cells against Aβ-toxicity. The study highlights the design of metal based anti-Alzheimer's disease (AD) systems.
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