Motivated by the mean field prediction of a Gardner phase transition between a "normal glass" and a "marginally stable glass", we investigate the off-equilibrium dynamics of three-dimensional polydisperse hard spheres, used as a model for colloidal or granular glasses. Deep inside the glass phase, we find that a sharp crossover pressure PG separates two distinct dynamical regimes. For pressure P < PG, the glass behaves as a normal solid, displaying fast dynamics that quickly equilibrate within the glass free energy basin. For P > PG, instead, the dynamics become strongly anomalous, displaying very large equilibration timescales, aging, and a constantly increasing dynamical susceptibility. The crossover at PG is strongly reminiscent of the one observed in three-dimensional spin-glasses in an external field, suggesting that the two systems could be in the same universality class, consistent with theoretical expectations.
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http://dx.doi.org/10.1039/c8sm00859k | DOI Listing |
Sci Adv
January 2025
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tissues form during development through mechanical compaction of their extracellular matrix (ECM) and shape morphing, processes that result in complex-shaped structures that contribute to tissue function. While observed in vivo, control over these processes in vitro to understand both tissue development and guide tissue formation has remained challenging. Here, we use combinations of mesenchymal stromal cell spheroids and hydrogel microparticles (microgels) with varied hydrolytic stability to fabricate programmable and dynamic granular composites that control compaction and tissue formation over time.
View Article and Find Full Text PDFVet Res Commun
January 2025
Department of Veterinary Medicine, University of Perugia, Via San Costanzo, 4, Perugia, 06126, Italy.
This study describes the congenital goiter in an alpaca (Vicugna pacos) fetus aborted in November 2021 with the clinical and pathological findings in the dam that was found dead on the farm three weeks after a miscarriage. The dam was a black coat alpaca bred in the Netherlands, imported in Italy in January 2021, and housed in a farm of central Italy for breeding purposes. Signalment and clinical data on dam and fetus were collected from the farmer and referring veterinarian.
View Article and Find Full Text PDFPLoS One
November 2024
Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, United Kingdom.
ACS Biomater Sci Eng
December 2024
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, United States.
Advancing three-dimensional (3D) tissue constructs is central to creating models and engineered tissues that recapitulate biology. Materials that are permissive to cellular behaviors, including proliferation, morphogenesis of multicellular structures, and motility, will support the emergence of tissue structures. Granular hydrogels in which there is no interparticle cross-linking exhibit dynamic properties that may be permissive to such cellular behaviors.
View Article and Find Full Text PDFSmall
January 2025
Soft Materials Laboratory - Institute of Materials in École Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland.
Direct ink writing (DIW) enables 3D printing of macroscopic objects with well-defined structures and compositions that controllably change over length scales of order 100 µm. Unfortunately, only a limited number of materials can be processed through DIW because it imparts stringent rheological requirements on inks. This limitation can be overcome for soft materials, if they are formulated as microparticles that, if jammed, fulfill the rheological requirements to be printed.
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