Objective: To identify the preconception risk factors in parents of children suffering from congenital cardiopathy.
Method: A cross-sectional descriptive study, which included parents of children suffering from cardiopathy, attended at consultations in a not-for-profit organization, in order to be diagnosed and referred for heart surgery or to be assessed in postoperative cardiac monitoring. The sample population included 500 people who responded to a survey for the identification of socio-demographic and preconception risk factors.
Results: Couples were found with up to 3 cardiac children. Parents with 2 or more children suffering from cardiopathy were classified in the majority as belonging to the middle socioeconomic level and not owning their own house. An association with the number of children with cardiopathy, the educational level of their parents (P=.013), their home area (P=.041) and type of accommodation (P=.045) was found. Regarding the preconception risk factors, there was evidence of statistically significant associations among the number of children with cardiopathy and their exposure to fertilizers (P=.024), their exposure to fuels (P=.025), the use of antihypertensive medication (P=.37), and alcohol consumption (P=.042) and cocaine use (P=.039) by their parents.
Conclusions: The population of parents with a greater number of children suffering from cardiopathy were characterized as having socioeconomic and educational constraints. The preconception risk factors which show an association with the number of children suffering from cardiopathy were characterized as physical and/or chemical environmental risk factors and the consumption of certain psychoactive substances and medication by their parents. It is necessary to analyze each risk factor separately, taking into account the different types of cardiopathy.
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http://dx.doi.org/10.1016/j.enfcli.2018.03.003 | DOI Listing |
Rev Gastroenterol Peru
January 2025
Department of Pathology, Santa Casa Hospital, Porto Alegre, Brazil.
Pancreatic ductal adenocarcinoma during pregnancy is extremely rare. Overall, including our case, only 19 cases confirmed antepartum have been reported to date. We report the case of a 37 year-old woman at 24 weeks of pregnancy in whom a pancreatic adenocarcinoma was identified during investigation of a suspected acute pancreatitis.
View Article and Find Full Text PDFHeadache
January 2025
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Objective: Our primary objective was to evaluate the safety and feasibility of transcranial direct current stimulation combined with exercise therapy for the treatment of cervicogenic headache. Our exploratory objectives compared symptoms of headache, mood, pain, and quality of life between active and sham transcranial direct stimulation combined with exercise therapy.
Background: Cervicogenic headache arises from injury to the cervical spine or degenerative diseases impacting cervical spine structure resulting in pain, reduced quality of life, and impaired function.
J Coll Physicians Surg Pak
January 2025
Department of Anaesthesiology, The Aga Khan University and Hospital, Karachi, Pakistan.
Objective: To explore the impact of perioperative intravenous (IV) paracetamol, administered with caudal ropivacaine on the quality of postoperative recovery in children undergoing hypospadias repair.
Study Design: Double-blinded randomised controlled trial. Place and Duration of the Study: The operating room, post-anaesthesia care unit (PACU), and paediatric surgical ward at the Aga Khan University Hospital, from 31st January 2019 to 1st May 2022.
Expert Rev Clin Pharmacol
January 2025
Department of Medical Cosmetology, Hunan Provincial Hospital of Maternal and Child Health Care.
Background: Anrikefon (HSK21542), a potent and selective peripheral kappa opioid receptor (KOR) agonist developed by Haisco, effectively blocks pain and itch signals.
Aim: To develop a population pharmacokinetic (PK) model for anrikefon and conduct exposure-response (E-R) analysis for safety and efficacy in postoperative pain patients.
Method: The Population PK analysis uses NONMEM software with data from six trials.
Trials
January 2025
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Background: Surgical intervention is critical in the treatment of hip developmental dysplasia in children. Perioperative analgesia, usually based on high opioid dosages, is frequently used in these patients. In some circumstances, regional anesthetic procedures such as caudal block and lumbar plexus block have also been used.
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