Aim: Determine qualitative and quantitative parameters of mouth and intestines microbiocenosis of healthy people in the age aspect to assess the status of the digestive tract microbiota, as an indicator of human health.
Materials And Methods: We examined 74 healthy subjects aged 12-18 years who have a comparative aspect investigated qualitative and quantitative composition of the oral fluid and feces microflora.
Results: The mouth and intestines microbiota of healthy people has a number of interrelated characteristics defined microbiota of the entire digestive tract The first time were described three variants of the mouth and intestines microbiota, characterized by a certain combination of obligate and facultasive microflora, depending on the age and livelihoods.
Conclusion: Definition ofmouth and intestines microbiocenosis can be used to assess the status of the digestive tract microbiora as an indicator of health and correction of outlined features through a rational manner of life, balanced diet, pre-and probiorics administration.
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J Oral Microbiol
January 2025
Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, Shenzhen City, Guangdong, China.
Background And Objective: Oral bacteria can translocate to the intestine, and their colonization efficiency is influenced by the gastrointestinal tract pH. Understanding how oral bacteria resist acidic environments is crucial for elucidating their role in gut health and disease.
Methods: To investigate the mechanisms of acid resistance in oral bacteria, an in vitro gastrointestinal tract Dynamic pH Model was established.
Dev Reprod
December 2024
Kidang Marine Science Institute, Jeju National University, Jeju 63333, Korea.
This study investigated the progressive morphological alterations and digestive tract development in larval and juvenile red spotted grouper, across growth stages. External shape observations were made using an optical microscope, and the development of the digestive tract was investigated using histological methods. At 1 day after hatching (DAH), the digestive tract appeared as a straight tube extending between the ventral side and yolk-sac.
View Article and Find Full Text PDFBMC Mol Cell Biol
January 2025
Department of Biochemistry, University at Buffalo, 3435 Main Street, Buffalo, NY, 14214, USA.
Background: Bioengineering of human teeth for replacement is an appealing regenerative approach in the era of gene therapy. Developmentally regulated transcription factors hold promise in the quest because these transcriptional regulators constitute the gene regulatory networks driving cell fate determination. Atonal homolog 1 (Atoh1) is a transcription factor of the basic helix-loop-helix (bHLH) family essential for neurogenesis in the cerebellum, auditory hair cell differentiation, and intestinal stem cell specification.
View Article and Find Full Text PDFClin Rheumatol
January 2025
Department of Rheumatology, Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Introduction/objectives: Sjogren's syndrome (SS) is a chronic inflammatory and difficult-to-treat autoimmune disease. Timosaponin AIII (TAIII), a plant-derived steroidal saponin, effectively inhibits cell proliferation, induces apoptosis, and exhibits anti-inflammatory properties. This study explored the mechanisms of action of TAIII in SS treatment by studying gut microbiota and short-chain fatty acids (SCFAs) using fecal metabolomics.
View Article and Find Full Text PDFComp Biochem Physiol B Biochem Mol Biol
January 2025
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address:
Yersinia ruckeri is known to cause enteric red mouth disease (ERM) in channel catfish (Ictalurus punctatus). This study established a model of Y. ruckeri-induced intestinal inflammation in channel catfish.
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