AI Article Synopsis
- A method utilizing calcium triflimide (Ca(NTf)) as a Lewis acid effectively activates sulfonyl fluorides for nucleophilic addition with amines.
- The reaction successfully transforms various types of sulfonyl fluorides and amines into sulfonamides.
- This process yields good results across a range of sterically and electronically diverse compounds.
Article Abstract
A method using calcium triflimide [Ca(NTf)] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233624 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.8b01520 | DOI Listing |
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