AI Article Synopsis
- Lipid metabolism disorders are linked to various health issues, including hyperlipidemia, obesity, and even cancer development due to abnormal gene and protein expression.
- Recent studies show that these disorders disrupt cytokines and signaling pathways, which can contribute to carcinogenesis.
- There is potential for lipid-lowering drugs to be used as effective cancer treatments, providing a less toxic alternative to traditional anti-cancer medications, highlighting the need for further research in this area.
Article Abstract
The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage disease, obesity and other related diseases. Intriguingly, recent studies have revealed that lipid metabolism disorders play an important role in carcinogenesis and development as well, since they cause abnormal expression of various genes, proteins, and dysregulation of cytokines and signaling pathways. More importantly, lipid-lowering drugs and anti-lipid per-oxidation treatment have been showing their advantages in clinic, in comparison with other anti-cancer drugs with high toxicity. Thus, further elucidation of molecular mechanism between lipid metabolism and cancer is essential in developing novel diagnostic biomarkers and therapeutic targets of human cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992506 | PMC |
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