Background: Metformin may lead to B deficiency and neuropathy. There are no published data on the prevalence of Metformin-related B deficiency and neuropathy in the Arabian Gulf.
Aims: Determine whether Metformin intake is associated with B deficiency and whether B deficiency is associated with diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy.
Methods: Patients with type 2 diabetes mellitus (T2DM) ( = 362) attending outpatient clinics at HMC underwent assessment of B levels, the DN4 questionnaire, and vibration perception threshold (VPT).
Results: Comparing Metformin to non-Metformin users there were no differences in B levels, VPT, or DN4. The prevalence of B deficiency (B <133 pmol/l) was lower ( < 0.01) in Metformin (8%) compared to non-Metformin (19%) users. Patients with B deficiency had a comparable prevalence and severity of sensory neuropathy and painful neuropathy to patients without B deficiency.
Conclusion: Serum B levels were comparable between Metformin and non-Metformin users with T2DM in Qatar. T2DM patients on Metformin had a lower prevalence of B deficiency. Furthermore, the prevalence and severity of neuropathy and painful diabetic neuropathy were comparable between patients with and without B deficiency.
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| http://dx.doi.org/10.3389/fendo.2018.00248 | DOI Listing |
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