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Background: The results of pulmonary vein isolation are limited by arrhythmia recurrence, which is most often due to a failure to effectuate a durable contiguous circumferential transmural lesion around the pulmonary vein (PV) ostia. We postulated that enhancing the index ablation line through use of multiple cryoballoon diameters would be superior to standard ablation with bonus freeze.

Methods: We enrolled 226 consecutive patients referred for cryoballoon-based PV isolation (PVI).

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Background: Catheter ablation (CA) is an effective therapeutic option for patients with symptomatic atrial fibrillation (AF). Previous studies have reported silent cerebral lesions (SCLs) detected by magnetic resonance imaging (MRI) after different CA techniques; however, the results were controversial. Therefore, we performed this network meta-analysis (NMA) to assess the incidence of SCLs after cryoballoon, hotballoon, laserballoon, and radiofrequency ablation (RFA).

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Background: The superior vena cava (SVC) acts as a non-pulmonary vein (PV) trigger for atrial fibrillation (AF) in 2%-6% of patients and harbours 25%-40% of non-PV foci. Approximately 10% of patients with AF have epicardial connections (ECs) between the atrium and PV inside the PV isolation lines, which are associated with AF recurrence. However, the contribution of EC(s) between the SVC and right atrium (RA) to subsequent AF remains unknown.

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Article Synopsis
  • Atrial tachyarrhythmia (ATA) recurrence is common after pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (PsAF), with a study showing a 79.7% freedom rate from ATA after 12 months.
  • Long intervals between PsAF diagnosis and ablation, as well as multiple prior unsuccessful treatments, are significant predictors of ATA recurrence following cryoballoon ablation (CBA).
  • The findings emphasize the importance of timely referral for treatment to potentially improve outcomes for PsAF patients undergoing CBA.
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Comparative analysis of left atrial size and appendage morphology in paroxysmal and persistent atrial fibrillation patients.

J Arrhythm

February 2025

Heart Center Munich-Bogenhausen, Department of Cardiology and Internal Intensive Care Medicine Munich Hospital Bogenhausen, Munich Municipal Hospital Group Munich Germany.

Purpose: Pulmonary vein isolation (PVI) is effective in treating atrial fibrillation (AF), but outcomes are worse for persistent AF (persAF) patients than paroxysmal AF (PAF) patients. The study aimed to identify differences in left atrial (LA) and left atrial appendage (LAA) anatomy in different AF types.

Methods: In a single-center observational study, a blinded retrospective analysis of preprocedural cardiac computed tomography angiography (CCTA) images was performed.

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