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CMV-Related Hemorrhagic Retinal Vasculitis in a Multiple Myeloma Patient on Daratumumab Therapy: A Case Report.
Ocul Immunol Inflamm
November 2024
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
Purpose: To report a case of cytomegalovirus (CMV)-related hemorrhagic retinal vasculitis in a patient with multiple myeloma (MM) on daratumumab, a trial cereblon E3 ligase modulatory drug (CELMoD), dexamethasone, and acyclovir, and discuss clinical implications for CMV prophylaxis.
Methods: Case report, narrative review of CMV reactivation risk in MM patients on daratumumab and antiviral agent efficacy for CMV prophylaxis.
Results: A 63-year-old female presented with 3 days of progressive unilateral vision loss in the right eye to the level of counting fingers.
Successful treatments of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome-related macular edema and exudation by intravitreal aflibercept injection in a senile patient: A case report.
Medicine (Baltimore)
September 2024
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Rationale: The prevalence of idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is <1/1,000,000, and it tends to occur in young women. Panretinal photocoagulation, focal laser photocoagulation, peripheral cryopexy, vitrectomy, and corticosteroid therapy are the traditional treatments. We reported a case of a senile patient with IRVAN syndrome who presented with severe exudation in both eyes and macular edema in the left eye, successfully treated by serial intravitreal aflibercept injections.
View Article and Find Full Text PDFCytomegalovirus retinitis with panretinal occlusive vasculopathy concealed by hypertensive uveitis: a case report.
J Yeungnam Med Sci
October 2024
Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea.
Article Synopsis
- Cytomegalovirus (CMV) retinitis is a rare condition, especially when it affects the anterior segment of the eye, as seen in a case study of a 72-year-old man who initially suffered from persistent corneal edema.
- The patient had high intraocular pressure (IOP) and unclear vision, and tests revealed complications like paracentral acute middle maculopathy (PAMM) and vasculopathy.
- Despite undergoing surgery and antiviral treatment, his vision did not improve, highlighting the challenging nature of diagnosing and treating simultaneous occurrences of hypertensive uveitis and CMV retinitis.
Bilateral Hemorrhagic Occlusive Retinal Vasculitis Induced by Osimertinib in a Patient with Non-Small Cell Lung Cancer.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, South Korea.
Purpose: To report a case of bilateral retinal vasculitis in a patient with non-small cell lung cancer undergoing treatment with osimertinib.
Case Report: A 58-year-old woman with lung adenocarcinoma (T4N3M1a stage IV) presented with blurry vision in both eyes (OU). Eighteen months before symptom onset, the treatment was changed from afatinib (20 mg/day) to osimertinib (80 mg/day) because of tumor progression.
Chronic Retinal Necrosis Associated with Toxoplasma Gondii.
Ocul Immunol Inflamm
June 2024
Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy.
Article Synopsis
- Chronic retinal necrosis is characterized by severe retinal inflammation and has been noted in patients with mild immune issues and conditions like CMV uveitis, often with negative HIV tests.
- Two specific cases are reported involving an 85-year-old woman and a 76-year-old man, both showing symptoms of advanced retinal disease related to long-term necrotizing retinitis.
- Testing revealed no herpesviruses but confirmed the presence of Toxoplasma gondii, suggesting that this organism should be included in the diagnosis for elderly patients with chronic retinal necrosis.
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