Objective: To describe and apply an optimal classification system for the management of ankylosing spondylitis (AS) that may be appropriate to make a preoperative surgical plan.
Background: The treatment choices of ankylosing spondylitis kyphosis remain controversial. The lack of a widely accepted classification system contributes to the variation in surgical decision making.
Methods: The classification is mainly based on radiographic findings. The sagittal deformity of spine in ankylosing spondylitis is classified according to three criteria: the location of the apex, the lumbar modifier (A, lumbar lordosis <0°, and B, lumbar kyphosis >0°) and the thoracic/thoracolumbar kyphosis severity modifier (- or +).
Results: The ankylosing spondylitis kyphosis can be divided into 4 types according to the location of the apex: Type I (lumbar), Type II (thoracolumbar), Type III (thoracic), Type IV (cervical or cervicothoracic junction). Either Type II or Type III is further divided into four subtypes based on the lumbar modifier and the thoracic/thoracolumbar kyphosis severity modifier: Type IIA-, Type IIA+, Type IIB-, Type IIB+, Type IIIA-, Type IIIA+, Type IIIB-, and Type IIIB+. Surgical decision making for AS kyphosis can be made according to the new classification.
Conclusion: This new classification system can be used effectively to classify AS kyphosis, which can be used to guide surgical decision making, including determining the site and the levels of osteotomies. Further research may be needed to validate the classification.
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http://dx.doi.org/10.1016/j.jspd.2017.06.001 | DOI Listing |
Inflamm Res
January 2025
Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, No. 350 Longzihu Road, Xinzhan District, Hefei, 230012, Anhui, China.
Objective: Arthritis is a class of diseases, characterized by joint and surrounding inflammation, accompanied by joint swelling, pain, dysfunction. According to different factors, arthritis can be divided into osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and so on. N6-methyladenosine (m6A) is the most common internal modification of eukaryotic mRNA and is involved in splicing, stabilization, output and degradation of RNA metabolism.
View Article and Find Full Text PDFRMD Open
January 2025
Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gastroenterology, Infectious Diseases and Rheumatology (including Nutrition Medicine), Charite Universitatsmedizin Berlin, Berlin, Germany.
Objectives: In this post-hoc analysis of ESTHER trial, we aimed to investigate the longitudinal relationship between inflammation on MRI and the achievement of inactive disease/low disease activity in patients with axial spondyloarthritis (axSpA) treated with long-term tumor necrosis factor (TNF) inhibitor etanercept.
Methods: Of the 76 patients with active axSpA in the ESTHER trial, we included all patients treated with etanercept for at least 6 months for main analysis. All clinical and MRI data from 4.
J Neurosurg Case Lessons
January 2025
Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois.
Background: Kyphotic spinal deformity is a complication of ankylosing spondylitis (AS). In rare cases, particularly in obese patients, the deformity might extend to the cervicothoracic spine, resulting in a severe "chin-on-abdomen" deformity. This condition severely impairs quality of life by affecting gaze, swallowing, and causing chronic pain.
View Article and Find Full Text PDFFront Immunol
January 2025
Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Background: Inflammation of the spine and sacroiliac joints is a hallmark of the chronic, progressive inflammatory illness known as ankylosing spondylitis (AS). The insidious onset and non-specific early symptoms of AS often lead to delays in diagnosis and treatment, which may result in the onset of disability. It is therefore imperative to identify new biomarkers.
View Article and Find Full Text PDFActa Med Philipp
November 2024
Department of Medicine, Makati Medical Center.
Axial Spondyloarthritis (SpA) is a chronic inflammatory disease of the spine associated with the gene HLA-B27. Non-radiographic spondyloarthritis (nr-SpA), an early stage of axial SpA often goes unrecognized in many settings including the Philippines. We describe five Filipinos from a tertiary health care facility who fulfill the Assessment of SpondyloArthritis International Society (ASAS) 2009 criteria for non-radiographic SpA with the aim of increasing awareness of this disease in the Philippines.
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