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Silymarin: a promising modulator of apoptosis and survival signaling in cancer.
Discov Oncol
January 2025
Department of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, 632014, India.
Cancer, one of the deadliest diseases, has remained the epicenter of biological research for more than seven decades. Yet all the efforts for a perfect therapeutic cure come with certain limitations. The use of medicinal plants and their phytochemicals as therapeutics has received much attention in recent years.
View Article and Find Full Text PDFPooling the complex survey data across the 64 lower and middle-income countries: A study on antibiotic usage in under-five children.
Heliyon
January 2025
Biostatistics, Epidemiology and Public Health Research Team, Department of Statistics, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
Background: Antibiotic exposure for fever/cough has been rising alarmingly, especially among children under five in low- and middle-income countries (LMICs). This excessive use could result in higher healthcare costs, and antibiotic resistance is an alarming trend in developing countries. As a result, it's crucial to look at the variables that affect antibiotic exposure and highlight the subgroups among whom antibiotic abuse is the most prevalent.
View Article and Find Full Text PDFIt's all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma.
J Neurooncol
January 2025
MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada.
Background: The receptor tyrosine kinase (RTK)/Ras/Raf/MEK/ERK signaling pathway is one of the most tumorigenic pathways in cancer, with its hyperactivation strongly linked to the aggressive nature of glioblastoma (GBM). Although extensive research has focused on developing therapeutics targeting this pathway, clinical success remains elusive due to the emergence of resistance mechanisms.
Objective: This review investigates how inhibition of the RTK/Ras/Raf/MEK/ERK pathway alters transcription factors, contributing to acquired resistance mechanisms in GBM.
Total joint arthroplasty of the thumb CMC joint.
Arch Orthop Trauma Surg
January 2025
Department of Orthopaedics and Traumatology, Second Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.
Purpose Of The Study: Rhizarthrosis-osteoarthritis of the thumb carpometacarpal (CMC) joint is usually a primary idiopathic disease. Total joint arthroplasty (TJA) is one of the surgical treatment options for symptomatic advanced thumb CMC arthritis. This retrospective study aims to evaluate the mid-term functional and radiological results of TJA with the minimum follow-up period of 3 years after the surgery.
View Article and Find Full Text PDFRecyclable Millable PolyureThane based on Enaminone Bonds With Upcycled Mechanical Performance.
Macromol Rapid Commun
January 2025
State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, China.
Thermoplastic polyurethane (TPU) exhibits re-processable properties, but the properties of TPU is deteriorated during the reprocessing for the oxidation and degradation of polymer chains. Meanwhile, although thermoset polyurethane exhibits excellent mechanical properties, it cannot be recycled for permanent crosslinking. Hence, it's still a challenge to obtain PU which exhibits the balance between the recyclability and mechanical properties.
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