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The contribution of clock genes BMAL1 and PER2 in osteoarthritis-associated pain.
Neurobiol Pain
December 2024
Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA.
Joint pain is the primary symptom of osteoarthritis (OA) and the main motivator for patients to seek medical care. OA-related pain significantly restricts joint function and diminishes quality of life. Despite the availability of various pain-relieving medications for OA, current treatment strategies often fall short in delivering adequate pain relief.
View Article and Find Full Text PDFExosomes: new targets for understanding axon guidance in the developing central nervous system.
Front Cell Dev Biol
January 2025
Key Laboratory of Tropical Translational Medicine and Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China.
Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles that are smaller than 100 nm, are secreted by most cell types in the brain. Regulation of cell-cell communication, neuroregeneration, and synapse formation by exosomes have been extensively studied.
View Article and Find Full Text PDFMambaTab: A Plug-and-Play Model for Learning Tabular Data.
Proc (IEEE Conf Multimed Inf Process Retr)
August 2024
Department of Computer Science, University of Kentucky, Lexington, KY, USA.
Despite the prevalence of images and texts in machine learning, tabular data remains widely used across various domains. Existing deep learning models, such as convolutional neural networks and transformers, perform well however demand extensive preprocessing and tuning limiting accessibility and scalability. This work introduces an innovative approach based on a structured state-space model (SSM), MambaTab, for tabular data.
View Article and Find Full Text PDFCarbon dots with red emission as nanoprobe for sensing of heparin in biofluids and pharmaceutical samples.
RSC Adv
January 2025
Medicinal Plants Research Center, Yasuj University of Medical Sciences Yasuj Iran.
Heparin (HEP) is one of the oldest anticoagulant drugs, widely used in clinical settings, particularly in surgery and dialysis machines. Despite its long history, it remains extensively employed in medical practice. This study introduces a selective and cost-effective method for the rapid detection of HEP using red-emission carbon dots (R-CDs).
View Article and Find Full Text PDFPlatelet rich plasma and anterior cruciate ligament repair: A new frontier, or a short term adjunct.
World J Orthop
January 2025
Department of Trauma and Orthopaedics, AOSP Terni, Terni 05100, Umbria, Italy.
Platelet rich plasma (PRP) is an autologous blood product rich in platelets, showing promise in reducing inflammation and accelerating healing. While extensively utilized in plastic surgery, dermatology, and osteoarthritis treatment, its application in anterior cruciate ligament (ACL) injuries is limited. This article examines PRP's potential in ACL reconstruction (ACLR), exploring its history, current usage, controversies and future directions.
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