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Mechanisms of cognitive impairment associated with cerebral infarction.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Cerebral infarction is a common type of stroke with high incidence and disability rates, and most patients experience varying degrees of cognitive impairment. The manifestations and severity of post-infarction cognitive impairment are influenced by multiple interacting factors, and its pathophysiological mechanisms are highly complex, involving pericyte degeneration, excessive generation of reactive oxygen species (ROS), overproduction of glutamate, and overactivation of autophagy. After cerebral infarction, abnormal pericyte function activates neuroinflammation and facilitates the entry of inflammatory mediators into the brain; detachment of pericytes from blood vessels disrupts the integrity of the blood-brain barrier.
View Article and Find Full Text PDFMitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet.
Free Radic Biol Med
March 2025
Department of Radiation Oncology, Mays Cancer Center at UT Health San Antonio MD Anderson, Joe R. and Teresa Lozano Long School of Medicine, UT Health San Antonio, TX, USA; Barshop Institute for Longevity and Aging Studies at UT Health San Antonio, TX, USA. Electronic address:
Acetyl-CoA Synthetase Short Chain Family Member-1 (ACSS1) catalyzes the ligation of acetate and coenzyme A to generate acetyl-CoA in the mitochondria to produce ATP through the tricarboxylic acid (TCA) cycle. We recently generated an ACSS1-acetylation (Ac) mimic knock-in mouse, where lysine 635 was mutated to glutamine (K635Q), which structurally and biochemically mimics an acetylated lysine. ACSS1 enzymatic activity is regulated, at least in part, through the acetylation of lysine 635 in mice (lysine 642 in humans), a Sirtuin 3 deacetylation target.
View Article and Find Full Text PDFResveratrol reduces RVLM neuron activity via activating the AMPK/Sirt3 pathway in stress-induced hypertension.
J Biol Chem
March 2025
School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China; School of Life Sciences, Shanghai University, Shanghai, China; College of Life Sciences, Dezhou University, Dezhou, Shandong, China; College of Agriculture and Bioengineering, Heze University, Heze, Shandong, China; Department of Preventive Medicine, Heze Medical College, Heze, Shandong, China; Shaoxing Institute of Shanghai University, Shaoxing, Zhejiang, China. Electronic address:
Neuronal hyperexcitability in the rostral ventrolateral medulla (RVLM), driven by oxidative stress, plays a crucial role in stress-induced hypertension (SIH). While resveratrol (RSV) is known for its antioxidant properties, its effects on RVLM neurons in SIH remain unclear. We investigated this using an SIH rat model exposed to electric foot shocks and noise stimulation for 15 days.
View Article and Find Full Text PDFMultidimensional analysis of selected bioelements in rat's brain subjected to stroke procedure and treatment with HS donor AP-39.
J Trace Elem Med Biol
March 2025
Department of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Krakow, Al. A. Mickiewicza, Kraków 30-059, Poland.
Background: A stroke is characterized by a sudden disruption in blood flow to the brain. According to WHO statistics, stroke is the second most common cause of death. Its pathophysiology involves complex mechanisms: oxidative stress, inflammation, cytotoxicity and neuronal cell death.
View Article and Find Full Text PDFVirulent African swine fever virus infection of porcine monocytes causes SLA I subversion due to loss of proper ER structure/function.
J Immunol
February 2025
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Immunology, Greifswald-Isle of Riems, Germany.
African swine fever virus (ASFV) is a large DNA virus of the Asfarviridae family that causes a fatal hemorrhagic disease in domestic swine and wild boar. Infections with moderately virulent strains predominantly result in a milder clinical course and lower lethality. As target cells of ASFV, monocytes play a crucial role in triggering T-cell-mediated immune defense and ASF pathogenesis.
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