Background: Obesity is associated with changes in the intestinal microbiome and methane-producing archaea may be involved in energy homeostasis.
Objective: The objective of this article is to investigate the associations between intestinal methane production, waist circumference and body mass index (BMI) as biomarkers for obesity.
Methods: Breath methane and hydrogen concentrations were measured over five hours following fructose or lactose ingestion in 1647 patients with functional gastrointestinal disorders. The relationships between gas concentrations and measures of obesity were investigated by stratifying gas concentration-time profiles by BMI and waist circumference, and, conversely, BMI and waist circumference by peak breath hydrogen and methane concentrations.
Results: Following fructose ingestion, patients with lower BMI and lesser waist circumference had greater breath methane concentrations (all < 0.003). Conversely, patients with increased methane concentrations had lower BMI ( < 0.001) and waist circumference ( = 0.02). After lactose ingestion, BMI and waist circumference were not associated with significant differences in methane. However, greater methane concentrations were associated with a lower BMI ( < 0.002), but not with waist circumference.
Conclusion: In this large group of patients mainly negative associations between breath methane concentrations and anthropometric biomarkers of obesity were evident. Studies investigating microbial methane production and energy homoeostasis in different populations are of substantial interest to distinguish epiphenomena from true causality.A follow-up study was registered at Clinical trials.gov NCT02085889.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987281 | PMC |
| http://dx.doi.org/10.1177/2050640617744457 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999-2018 study.
Diabetol Metab Syndr
January 2025
Rehabilitation Medicine Center, Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Background: As cardiovascular disease (CVD) morbidity and mortality increase yearly, this study aimed to explore the potential of the weight-adjusted-waist index (WWI) and its relation to long-term mortality in patients with CVD.
Methods: The diagnosis of CVD was based on standardized medical condition questionnaires that incorporated participants' self-reported physician diagnoses. WWI (cm/√kg) is a continuous variable and calculated as waist circumference (WC, cm) divided by square root of body weight (kg).
Consistency between the geographic distributions of overweight and obesity among children and adults in China.
BMC Public Health
January 2025
School of Public Health, North Sichuan Medical College, No. 234 Fujiang Road, Nanchong, 637000, Sichuan, China.
Background: Childhood obesity is associated with obesity in adulthood, but the consistency between the geographic distributions of obesity among children and adults in China is not fully understood. We aimed to examine the consistency of the geographic distributions of overweight and obesity between adults and children in China.
Methods: This was a cross-sectional study including 11,940 adults.
Diabetic microvascular complications are associated with left ventricular hypertrophy in patients with type 2 diabetes mellitus.
J Diabetes Complications
December 2024
Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing 101149, China. Electronic address:
Background: Left ventricular hypertrophy (LVH) is an important and common pathologic change in the heart of patients with diabetes mellitus. Microvascular complications have been reported to be involved in the development and process of LVH. This study aimed to explore the association between diabetic microvascular complications and LVH in patients with type 2 diabetes mellitus (T2DM).
View Article and Find Full Text PDFImprovement of measured and perceived disability in overweight patients with Multiple Sclerosis trough different patterns of Mediterranean hypocaloric diet.
Mult Scler Relat Disord
January 2025
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. Electronic address:
Objectives: overweight and other cardiovascular risk factors are known contributors to disability accrual in Multiple Sclerosis (MS). We aimed to explore the impact of three hypocaloric dietetic patterns, based on the Mediterranean diet, on cardiovascular risk and clinical status in overweight persons with MS (pwMS).
Material And Methods: overweight pwMS (body mass index-BMI ≥25 kg/m) were prospectively enrolled, randomly allocated to three hypocaloric dietetic plans differing in macronutrients composition (carbohydrates/proteins/lipids: diet A 65 %/15 %/20 %; diet B 35 %/25 %/40 %; diet C 50 %/20 %/30 %) and followed-up for 1 year (6 months of dietetic intervention + 6 months of observation).
Predicting Body Fat Percentage from Anthropometric Measurements in Asian Athletes.
J Sci Sport Exerc
November 2024
Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, IN 47403, USA.
Purpose: Researchers have predicted body fat percentage (BF%), as indicated by dual energy X-ray absorptiometry (DXA), from skinfold thicknesses in North American and European athletes, but not athletes from other regions. We sought to estimate an equation to predict BF% in elite Asian athletes from their skinfold thickness and girth measurements, with DXA as a reference method.
Methods: We collected data from two samples of athletes on Singaporean national teams.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!