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Functional respiratory imaging: heterogeneity of acute exacerbations of COPD. | LitMetric

AI Article Synopsis

  • Exacerbations of COPD are complex and vary significantly among patients, which challenges the effectiveness of standard treatments; this study aims to explore these differences through functional respiratory imaging (FRI).
  • The trial involved 47 patients with acute COPD exacerbations, using FRI and other assessments to evaluate respiratory function during the acute phase and recovery.
  • Results indicated notable improvements in lung mechanics and airway resistance, suggesting that FRI can highlight individual variations in COPD exacerbations, paving the way for more personalized treatment approaches.

Article Abstract

Background: Exacerbations of COPD are a major burden to patients, and yet little is understood about heterogeneity. It contributes to the current persistent one-size-fits-all treatment. To replace this treatment by more personalized, precision medicine, new insights are required. We assessed the heterogeneity of exacerbations by functional respiratory imaging (FRI) in 3-dimensional models of airways and lungs.

Methods: The trial was designed as a multicenter trial of patients with an acute exacerbation of COPD who were assessed by FRI, pulmonary function tests, and patient-reported outcomes, both in the acute stage and during resolution.

Results: Forty seven patients were assessed. FRI analyses showed significant improvements in hyperinflation (a decrease in total volume at functional residual capacity of -0.25±0.61 L, ≤0.01), airway volume at total lung capacity (+1.70±4.65 L, =0.02), and airway resistance. As expected, these improvements correlated partially with changes in the quality of life and in conventional lung function test parameters. Patients with the same changes in pulmonary function differ in regional disease activity measured by FRI.

Conclusion: FRI is a useful tool to get a better insight into exacerbations of COPD, and significant improvements in its indices can be demonstrated from the acute phase to resolution even in relatively small groups. It clearly visualizes the marked variability within and between individuals in ventilation and resistance during exacerbations and is a tool for the assessment of the heterogeneity of COPD exacerbations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985851PMC
http://dx.doi.org/10.2147/COPD.S152463DOI Listing

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