Objective: Parents may rely on information provided by extended family members when making decisions concerning the health of their children. We evaluate whether extended family members affected the success of an information intervention promoting infant health.
Methods: This is a secondary, sequential mixed-methods study based on a cluster randomised controlled trial of a peer-led home-education intervention conducted in Mchinji District, Malawi. We used linear multivariate regression to test whether the intervention impact on child height-for-age z-scores (HAZ) was influenced by extended family members. 12 of 24 clusters were assigned to the intervention, in which all pregnant women and new mothers were eligible to receive 5 home visits from a trained peer counsellor to discuss infant care and nutrition. We conducted focus group discussions with mothers, grandmothers and peer counsellors, and key-informant interviews with husbands, chiefs and community health workers to better understand the roles of extended family members in infant feeding.
Results: Exposure to the intervention increased child HAZ scores by 0.296 SD (95% CI 0.116 to 0.484). However, this effect is smaller in the presence of paternal grandmothers. Compared with an effect size of 0.441 to 0.467 SD (95% CI -0.344 to 1.050) if neither grandmother is alive, the effect size was 0.235 (95% CI -0.493 to 0.039) to 0.253 (95% CI -0.529 to 0.029) SD lower if the paternal grandmother was alive. There was no evidence of an effect of parents' siblings. Maternal grandmothers did not affect intervention impact, but were associated with a lower HAZ score in the control group. Qualitative analysis suggested that grandmothers, who act as secondary caregivers and provide resources for infants, were slower to dismiss traditionally held practices and adopt intervention messages.
Conclusion: The results indicate that the intervention impacts are diminished by paternal grandmothers. Intervention success could be increased by integrating senior women.
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http://dx.doi.org/10.1136/bmjopen-2017-019380 | DOI Listing |
Cancers (Basel)
January 2025
Department of Medicine, The Masonic Cancer Center, The University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Desmoid-type fibromatosis (DTF) is a locally invasive tumor composed of myofibroblast-like cells and collagen; it does not metastasize but can cause significant local morbidity. Most sporadic cases are associated with mutations in the CTNNB1 gene, which encodes beta-catenin. Various treatments have been used with differing efficacy and toxicity profiles.
View Article and Find Full Text PDFHealthcare (Basel)
January 2025
Institute of Health and Sport, Victoria University, Melbourne, VIC 8001, Australia.
Families with young children with developmental disabilities often express concerns about delays in the identification of these and extended waiting times for obtaining assessments, learning support, and rehabilitation services. The identification process must and can be enhanced if preschool teachers have instrumental measures to detect early-stage developmental disabilities and adjustment difficulties in preschool children and, if necessary, to provide these children with prompt and effective support services. The aim with this study was to develop and validate a screening checklist for teachers to detect developmental delays and adjustment difficulties in Chinese preschool children in Hong Kong.
View Article and Find Full Text PDFJ Magn Reson
January 2025
Center for Magnetic Resonance Research, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA. Electronic address:
In this work the effect of the geometric phase on time evolution of the density matrix was evaluated during nonadiabatic radiofrequency (RF) pulses with Sine amplitude modulation (AM) and Cosine frequency modulation (FM) functions of the RAFF (Relaxations Along a Fictitious Field) family, and the polarization between two energy level ½ spin system coupled by dipolar interaction was evaluated during the application of RF irradiation. The dependencies of the diagonal density matrix elements and the polarization on the rotational correlation times and the time during RF pulses were evaluated. The general treatment of the density matrix elements along with the polarization generated during RF pulses was unavailable thus far, and for the first time was here derived for the nonadiabatic case of the RAFF pulses.
View Article and Find Full Text PDFPLoS One
January 2025
Glycologix, Inc., 100 Cummings Center, Beverly, Massachusetts, United States of America.
Chemical modification of naturally derived glycosaminoglycans (GAGs) expands their potential utility for applications in soft tissue repair and regenerative medicine. Here we report the preparation of a novel crosslinked chondroitin sulfate (~200 to 2000 kilodaltons) that is both soluble in aqueous solution and microfilterable. We refer to these materials as "SuperGAGs.
View Article and Find Full Text PDFJ Head Trauma Rehabil
January 2025
Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, Minnesota (Tsen); Department of Physical Medicine and Rehabilitation, Rehabilitation & Extended Care, Minneapolis VA Health Care System, Minneapolis, Minnesota (Dr Finn); Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota (Dr Finn); Department of Research Methodology and Biostatistics, Morsani College of Medicine, University of South Florida, Tampa, Florida (Mrs Klocksieben); Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts (O'Neil-Pirozzi); Department of Communication Sciences & Disorders, Northeastern University, Boston, Massachusetts (Dr O'Neil-Pirozzi); H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas (Dr Sander); Brain Injury Research Center, TIRR Memorial Hermann, Houston, Texas (Dr Sander); Department of Research, Craig Hospital, Englewood, Colorado (Drs Agtarap and Finn); Departments of Ophthalmology & Visual Sciences and Physical Medicine & Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama (Dr Dreer); Research Service, James A. Haley Veterans Hospital, Tampa, Florida (Dr Cotner); Research Service, Traumatic Brain Injury Center of Excellence at James A. Haley Veterans Hospital, Tampa, Florida (Drs Cotner and Nakase-Richardson); Research Department, Central Virginia Veterans Affairs Health Care System, Richmond, Virginia (Mss Vargas, and Dini, and Dr Perrin); Department of Psychology, Virginia Commonwealth University, Richmond, Virginia (Ms Vargas); Department of Psychology, University of Virginia, Charlottesville, Virginia (Ms Dini and Dr Perrin); Mental Health, School of Data Science, University of Virginia, Charlottesville, Virginia (Dr Perrin); Mental Health and Behavioral Services, James A. Haley Veterans Hospital, Tampa, Florida (Drs Finn and Nakase-Richardson); and Department of Internal Medicine, Pulmonary and Sleep Medicine Division, University of South Florida, Tampa, Florida (Dr Nakase-Richardson).
Objective: To describe the self-reported needs of family caregivers of service members and veterans (SMVs) with traumatic brain injury (TBI) at 10 to 15 years post-injury and to identify unique predictors of unmet family needs.
Setting: Five Department of Veterans Affairs Polytrauma Rehabilitation Centers.
Participants: A total of 209 family caregivers of SMVs with TBI from the VA TBI Model Systems national database who completed a 10- or 15-year follow-up assessment.
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