Beware of Undertow: Opioid Drugs Generate Additional Waves of Intracellular Signaling.

Neuron

Department of Anesthesiology, Perioperative and Pain Medicine, Department of Neurosurgery, Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA; New York Stem Cell Foundation - Robertson Investigator, Stanford University, Palo Alto, CA 94304, USA. Electronic address:

Published: June 2018

In this issue of Neuron, Stoeber et al. (2018) report a biosensor resolving the spatiotemporal organization of opioid receptor activation in living neurons. They delineate novel signaling mechanisms in endosomes and Golgi differentially engaged by opioid peptides and drugs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492023PMC
http://dx.doi.org/10.1016/j.neuron.2018.05.035DOI Listing

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