Unlabelled:  Lipoma arborescens is a rare intra-articular benign tumor. It affects mostly the knee and the diagnosis is usually difficult due to resembling symptomatology of osteoarthritis.

Cases Presentation: We report herein 3 new cases of lipoma arborescens of the knee in which a patient has synovitis associated. In 2 cases, the discovery was intraoperatively. We also report a tumor relapse 2 years after surgery.

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Lipoma arborescens in a 22-year-old male: A case report.

Medicine (Baltimore)

December 2024

Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.

Rationale: Lipoma arborescens (LA) is a rare, benign proliferative disorder of the synovial lining that typically affects middle-aged individuals, predominantly in the knee joint. However, its occurrence in younger patients is unusual and may pose unique diagnostic and therapeutic challenges. This case report aims to highlight the clinical, imaging, and therapeutic aspects of LA in a young adult, thereby expanding the understanding of its presentation in this age group.

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Adipose tissue around the knee; A pictorial review of normal anatomy and common pathologies.

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Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, Seattle, WA, USA. Electronic address:

The periarticular adipose tissues play a crucial role in knee biomechanics, yet they are often overlooked in daily radiology practice. As the primary mechanical shock absorbers of the knee, intra-articular fat pads reduce the friction between intra-articular structures during joint movement. They also contribute to inflammatory regulation, endocrine secretion, and pain detection.

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Article Synopsis
  • Synovial lipomatosis is a rare, benign condition affecting the synovial lining of joints, primarily the knee, and is characterized by the presence of mature fat infiltrating the joint tissue, causing pain and swelling.
  • It typically leads to joint movement restrictions and can occur in other joints like the hip and ankle, but diagnosis is often challenging due to its rarity and unclear causes.
  • Treatment options range from conservative management to surgical intervention; in this case, a 47-year-old male underwent surgery for severe symptoms, including arthroscopic debridement and synovectomy.
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A 78-year-old Thai male presented with chronic bilateral knee pain and swelling. X-ray imaging revealed osteoarthritis in both knees, with a suspicious soft tissue shadow. Magnetic resonance imaging suggested lipoma arborescens (LA).

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Synovial lipomatosis or lipoma arborescens is a very uncommon pseudo-tumorous lesion of the synovium which more commonly affects the knee joint. The most probable cause of this pathological lesion is degenerative articular disorders of the joint and improper fat accumulation. It is characterized by presence of villous proliferation of the synovium and replacement of the sub-synovial tissue by mature adipocytes which is infiltrated by dense chronic inflammatory cells like lymphocytes, plasma cells and eosinophils.

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