AI Article Synopsis
- A 76-year-old woman presented with anasarca, fever, thrombocytopenia, reticulin fibrosis, and acute kidney injury, leading to the diagnosis of TAFRO syndrome.
- Initial treatments included renal replacement therapy and steroids; however, as her kidney function improved, she developed nephrotic syndrome.
- A kidney biopsy revealed significant macrophage infiltration and a condition resembling membranoproliferative glomerulonephritis, indicating the complexity of kidney dysfunction in TAFRO syndrome, though its underlying mechanisms remain unclear.
Article Abstract
A 76-year-old woman suddenly developed anasarca and a fever, and an examination revealed thrombocytopenia, reticulin fibrosis, and acute kidney injury, yielding the diagnosis of thrombocytopenia, anasarca, fever, reticulin fibrosis, organomegaly (TAFRO) syndrome. Renal replacement therapy and steroid treatment were soon started. Her proteinuria was minor at first; however, once the kidney function improved, nephrotic syndrome occurred. A kidney biopsy showed membranoproliferative glomerulonephritis-like glomerulopathy with massive macrophage infiltration. Although kidney dysfunction is often observed in TAFRO syndrome patients, its detailed mechanism is unclear. This case suggests that TAFRO syndrome involves both acute kidney injury with minor proteinuria and nephrotic syndrome, and these disorders can develop serially in the same patient.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262707 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.0806-18 | DOI Listing |
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