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Here, we report a case of a 67-year-old man who had septic shock due to Citrobacter braakii infection during the course of chemotherapy with high-dose cytosine arabinoside for acute myeloid leukemia. Treatment with cefepime rapidly improved his condition. The number of reported cases of sepsis due to Citrobacter braakii is limited. Further accumulation of cases is necessary to obtain accurate data such as the risk factors for Citrobacter braakii infections.
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| http://dx.doi.org/10.11406/rinketsu.59.492 | DOI Listing |
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Article Synopsis
- Citrobacter braakii (C. braakii) is a gram-negative, anaerobic bacterium linked to inflammation in various human tissues, but its role in gastric mucosa inflammation remains unclear.
- In a study, C. braakii was found in 35.5% of patients with chronic gastritis and was associated with increased severity of mucosal inflammation.
- Specific strain C. braakii P1 showed urease activity, adherence to gastric cells, and induced proinflammatory responses (like IL-8 and TNF-α) significantly more in gastric cells compared to others, implying its potential role in gastric disease.
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