The somatic hot spot mutation STAT5B was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5B expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964446 | PMC |
| http://dx.doi.org/10.1080/23723556.2018.1435181 | DOI Listing |
Publication Analysis
Top Keywords
haunted beast
4
beast targeting
4
targeting stat5b
4
stat5b t-cell
4
t-cell neoplasia
4
neoplasia somatic
4
somatic hot
4
hot spot
4
spot mutation
4
mutation stat5b
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!