AI Article Synopsis
- Morphea, or localized scleroderma, is a skin condition characterized by sclerosus that affects the skin and subcutaneous tissue, but does not involve Raynaud's phenomenon or internal organs.
- Some forms can have noticeable effects on function and appearance, making early treatment of inflammation important.
- The study discusses the epidemiology, clinical features, treatment options, and progression of various morphea forms, based on a series of 24 cases.
Article Abstract
Morphea, also known as localized scleroderma, is defined as a sclerosus skin condition that can extend to the subcutaneous tissue but with no Raynaud's phenomenon or visceral involvement. Some clinical forms may have a functional and aesthetic impact, hence the interest of treatment of early stage inflammation. We here describe the epidemio-clinical, therapeutic and evolutionary features of different forms of morphea, by reporting a series of 24 cases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987154 | PMC |
| http://dx.doi.org/10.11604/pamj.2018.29.53.11592 | DOI Listing |
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Article Synopsis
- Morphea, or localized scleroderma, is an autoimmune disease marked by excessive collagen buildup in the skin, with unclear causes that may include genetic, environmental, and epigenetic factors.
- Advances in medicine suggest genetic and epigenetic influences may significantly impact the disease's risk and progression, highlighting the role of factors like microRNAs and DNA methylation.
- New treatment options, including biological therapies and JAK inhibitors, show promise based on case studies, underscoring the need for further exploration of morphea's pathogenesis and treatment strategies.
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