AI Article Synopsis
- Cellular stress triggers various changes in cells, especially during infections and nutritional variations.
- Autophagy is a key response mechanism, helping cells manage stress by degrading and recycling damaged components.
- The review focuses on how autophagy detects intracellular bacteria and the strategies some bacteria use to evade this cellular cleanup process.
Article Abstract
Cellular responses to stress can be defined by the overwhelming number of changes that cells go through upon contact with and stressful conditions such as infection and modifications in nutritional status. One of the main cellular responses to stress is autophagy. Much progress has been made in the understanding of the mechanisms involved in the induction of autophagy during infection by intracellular bacteria. This review aims to discuss recent findings on the role of autophagy as a cellular response to intracellular bacterial pathogens such as, , how the autophagic machinery senses these bacteria directly or indirectly (through the detection of bacteria-induced nutritional stress), and how some of these bacterial pathogens manage to escape from autophagy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974045 | PMC |
| http://dx.doi.org/10.3389/fimmu.2018.00935 | DOI Listing |
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