Cephalopod Tissue Regeneration: Consolidating Over a Century of Knowledge.

Regeneration, a process consisting in regrowth of damaged structures and their functional recovery, is widespread in several phyla of the animal kingdom from lower invertebrates to mammals. Among the regeneration-competent species, the actual ability to restore the full form and function of the injured tissue varies greatly, from species being able to undergo whole-body and internal organ regeneration, to instances in which this ability is limited to a few tissues. Among invertebrates, cephalopod mollusks retain the ability to regenerate several structures (i.e., muscles, nerves, or entire appendages). Here we provide an overview of more than one-hundred studies carried out over the last 160 years of research. Despite the great effort, many aspects of tissue regeneration in cephalopods, including the associated molecular and cellular machinery, remain largely unexplored. Our approach is largely descriptive and aims to provide a reference to prior work thus to facilitate future research efforts. We believe such research may lead to important discoveries and approaches that can be applied to other animal taxa including higher vertebrates, as well as other research fields such as regenerative medicine.