AI Article Synopsis
- Marine actinobacteria are valuable for discovering unique secondary metabolites, leading to the isolation of a new siderophore called albisporachelin from strain WP1.
- This strain was obtained from deep-sea sediments in the Indian Ocean at a depth of -2945 m and produces the siderophore in iron-depleted conditions.
- The structure of albisporachelin was determined using various analytical techniques including 1D and 2D NMR and MS/MS analyses.
Article Abstract
Marine actinobacteria continue to be a rich source for the discovery of structurally diverse secondary metabolites. Here we present a new hydroxymate siderophore produced by , a recently described species of this less explored actinomycete genus. Strain WP1 was isolated from sediments collected at -2945 m in the Indian Ocean. The new siderophore, designated albisporachelin, was isolated from iron depleted culture broths and the structure was established by 1D and 2D NMR and MS/MS experiments, and application of a modified Marfey's method. Albisporachelin is composed of one -methylated-formylated/hydroxylated l-ornithine (-Me-fh-l-Orn), one l-serine (l-Ser), one formylated/hydroxylated l-ornithine (fh-l-Orn) and a cyclo--methylated-hydroxylated l-ornithine (cyclo--Me-h-l-Orn).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024995 | PMC |
| http://dx.doi.org/10.3390/md16060199 | DOI Listing |
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Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete WP1.
Mar Drugs
June 2018
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Article Synopsis
- Marine actinobacteria are valuable for discovering unique secondary metabolites, leading to the isolation of a new siderophore called albisporachelin from strain WP1.
- This strain was obtained from deep-sea sediments in the Indian Ocean at a depth of -2945 m and produces the siderophore in iron-depleted conditions.
- The structure of albisporachelin was determined using various analytical techniques including 1D and 2D NMR and MS/MS analyses.
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