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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116734 | PMC |
| http://dx.doi.org/10.1016/j.cmet.2018.04.018 | DOI Listing |
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JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.
Cell Metab
January 2018
Department of Immuno-Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA. Electronic address:
Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance.
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