[CLINICAL EFFICACY OF TREATMENT OF STAPHYLOCOCCAL INFECTION BY COMPOSITION OF NANOSTRUCTURED SILICON DIOXIDE AND FOSFOMYCIN.].

Clinical efficacy of a composition of nanostructuared silicon dioxide and fosfomycin in treating the skin abscess induced by Staphylococcus aureus inoculation in rabbits has been studied. It is established that the proposed composition of silicon dioxide nanoparticles and fosfomycin exhibits higher therapeutic potential in treating local purulent-septic process in skin of test animals. The therapy with this composition reduced the number of abscesses in the skin by 50% after two days of application and by 80 - 90% after five days of therapy as compared to therapy with application of chloramphenicol liniment (15.0 vs. 4.0 and 7.0 vs. 2.0, respectively).