Neuromeningeal prophylaxis for diffuse large B-cell lymphoma.

The neuromeningeal relapse of diffuse large B-cell lymphomais a rare complication with a poor prognosis due to early mortality. Some risk factors are associated with an increased risk of neuromeningeal relapse: elevated LDH, more than one extranodal site and certain anatomical sites. Place and methods of neuromeningeal prophylaxis are points that remain to be defined. In this review we underwent an extensive search of literature and we reviewed the incidence of CNS relapse in diffuse large B-cell lymphomaand we outlined different strategies of administering CNS prophylaxis and we discussed their advantages and drawbacks.