AI Article Synopsis
- - A new method combining chemo- and biocatalysis was developed for creating hydroxy ketones and 1,3-diols in a stereoselective manner.
- - This method utilized innovative tridentate N,N,O ligands with copper(II) complexes, achieving effective asymmetric β-borylation of α,β-unsaturated compounds.
- - Yeasts were then employed to bioreduce the resulting keto-alcohols, leading to high yields of enantiomerically enriched products with up to 99% selectivity.
Article Abstract
A chemo- and biocatalytic cascade approach was applied for the stereoselective synthesis of hydroxy ketones and the corresponding 1,3-diols. A new class of tridentate N,N,O ligands was used with copper(II) complexes for the asymmetric β-borylation of α,β-unsaturated compounds. The complex containing ligand emerged as the best performer, and it gave the organoborane derivatives with good values. The corresponding keto-alcohol compounds were then bioreduced by yeasts. The biotransformation set up with allowed ()-keto-alcohols and (,)-diols to be obtained with up to 99 % and up to 99 % in favor of the enantiomers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974551 | PMC |
| http://dx.doi.org/10.1002/open.201800056 | DOI Listing |
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