Rapidly involuting congenital haemangiomas (RICHs) are rare benign vascular tumours of infancy. They are generally asymptomatic, but can present with thrombocytopaenia and coagulopathy. Significant complications including life-threatening bleeding, high-output heart failure and liver failure, though rare, can occur. RICHs generally regress by 12-14 months of age and can be managed clinically with symptomatic treatment, watchful waiting and close monitoring of the size of the haemangioma. Medical management (corticosteroids, propranolol) has not shown to be effective, in contrast to infantile haemangioma which will not regress spontaneously and has been noted to respond to medical therapy. Awareness of this diagnosis is important to prevent unnecessary medical and surgical intervention. Here, we present a case of a full-term infant with RICH who presented with thrombocytopaenia and abnormal coagulation profile. The coagulopathy was treated symptomatically, while the lesion was observed with serial ultrasounds and gradually decreased in size.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990102PMC
http://dx.doi.org/10.1136/bcr-2018-224337DOI Listing

Publication Analysis

Top Keywords

rapidly involuting
8
involuting congenital
8
congenital haemangioma
4
haemangioma liver
4
liver rapidly
4
congenital haemangiomas
4
haemangiomas richs
4
richs rare
4
rare benign
4
benign vascular
4

Similar Publications

Article Synopsis
  • This study focused on congenital hepatic hemangiomas (CHHs) in children, investigating their clinical characteristics and how management strategies have changed over the past two decades.
  • A total of 211 patients were analyzed, identifying four subtypes of CHHs, with most patients experiencing different rates of involution (size reduction) of the hemangiomas based on their subtype.
  • The research revealed a significant increase in the use of expectant management (monitoring without invasive treatment), rising from 35.4% to 77.7% from 2003-2012 to 2013-2022, while maintaining a high survival rate of 98.6% among patients.
View Article and Find Full Text PDF
Article Synopsis
  • Distinguishing between benign and potentially malignant skin tumors is crucial in family medicine, and many benign tumors can be diagnosed based on their history, appearance, and growth patterns.
  • Procedures like biopsy or excision may be necessary if there's uncertainty about a diagnosis or if the lesion changes rapidly.
  • Treatment options vary based on the type of lesion and patient preference, with methods like excision, laser therapy, and cryotherapy commonly used; special considerations are needed for patients with darker skin to minimize risks like hypopigmentation.
View Article and Find Full Text PDF

The adult mammary gland is maintained by lineage-restricted progenitor cells through pregnancy, lactation, involution, and menopause. Injury resolution, transplantation-associated mammary gland reconstitution, and tumorigenesis are unique exceptions, wherein mammary basal cells gain the ability to reprogram to a luminal state. Here, we leverage newly developed cell-identity reporter mouse strains, and time-resolved single-cell epigenetic and transcriptomic analyses to decipher the molecular programs underlying basal-to-luminal fate switching .

View Article and Find Full Text PDF

This study aimed to evaluate the impacts of supplemental dietary curcumin on post-partum uterine involution using pulsed-wave Doppler ultrasonography in postpartum goats. Ten pluriparous Zaraibi goats were used and divided into two groups. Group 1 (n = 5; control) received only a base diet.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!